A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex

Through a rapid screening of Cp*Ir complexes based on a turn‐on type fluorescence readout, a [Cp*Ir(dipyrido[3,2‐a : 2’,3’‐c]phenazine)Cl](+) complex was found to catalyze the blue‐light promoted dehydrogenation of N‐heterocycles under physiological conditions. In the dehydrogenation of tetrahydrois...

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Detalles Bibliográficos
Autores principales: Davis, Holly Jane, Häussinger, Daniel, Ward, Thomas R., Okamoto, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984327/
https://www.ncbi.nlm.nih.gov/pubmed/33777249
http://dx.doi.org/10.1002/cctc.202000488
Descripción
Sumario:Through a rapid screening of Cp*Ir complexes based on a turn‐on type fluorescence readout, a [Cp*Ir(dipyrido[3,2‐a : 2’,3’‐c]phenazine)Cl](+) complex was found to catalyze the blue‐light promoted dehydrogenation of N‐heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H(2)O(2) generation. We surmise that this mechanism may be reminiscent of flavin‐dependent oxidases.

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