A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex

Through a rapid screening of Cp*Ir complexes based on a turn‐on type fluorescence readout, a [Cp*Ir(dipyrido[3,2‐a : 2’,3’‐c]phenazine)Cl](+) complex was found to catalyze the blue‐light promoted dehydrogenation of N‐heterocycles under physiological conditions. In the dehydrogenation of tetrahydrois...

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Detalles Bibliográficos
Autores principales: Davis, Holly Jane, Häussinger, Daniel, Ward, Thomas R., Okamoto, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984327/
https://www.ncbi.nlm.nih.gov/pubmed/33777249
http://dx.doi.org/10.1002/cctc.202000488
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author Davis, Holly Jane
Häussinger, Daniel
Ward, Thomas R.
Okamoto, Yasunori
author_facet Davis, Holly Jane
Häussinger, Daniel
Ward, Thomas R.
Okamoto, Yasunori
author_sort Davis, Holly Jane
collection PubMed
description Through a rapid screening of Cp*Ir complexes based on a turn‐on type fluorescence readout, a [Cp*Ir(dipyrido[3,2‐a : 2’,3’‐c]phenazine)Cl](+) complex was found to catalyze the blue‐light promoted dehydrogenation of N‐heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H(2)O(2) generation. We surmise that this mechanism may be reminiscent of flavin‐dependent oxidases.
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spelling pubmed-79843272021-03-24 A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex Davis, Holly Jane Häussinger, Daniel Ward, Thomas R. Okamoto, Yasunori ChemCatChem Communications Through a rapid screening of Cp*Ir complexes based on a turn‐on type fluorescence readout, a [Cp*Ir(dipyrido[3,2‐a : 2’,3’‐c]phenazine)Cl](+) complex was found to catalyze the blue‐light promoted dehydrogenation of N‐heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H(2)O(2) generation. We surmise that this mechanism may be reminiscent of flavin‐dependent oxidases. John Wiley and Sons Inc. 2020-07-22 2020-09-17 /pmc/articles/PMC7984327/ /pubmed/33777249 http://dx.doi.org/10.1002/cctc.202000488 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Davis, Holly Jane
Häussinger, Daniel
Ward, Thomas R.
Okamoto, Yasunori
A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title_full A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title_fullStr A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title_full_unstemmed A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title_short A Visible‐Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex
title_sort visible‐light promoted amine oxidation catalyzed by a cp*ir complex
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984327/
https://www.ncbi.nlm.nih.gov/pubmed/33777249
http://dx.doi.org/10.1002/cctc.202000488
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