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Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans
Despite a great improvement in target volume dose conformality made possible in recent years by modulated therapies, xerostomia remains a common and severe side effect for head‐and‐neck radiotherapy patients. It is known that parotid glands exhibit a spatially varying dose response; however, the rel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984464/ https://www.ncbi.nlm.nih.gov/pubmed/33565210 http://dx.doi.org/10.1002/acm2.13192 |
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author | Sample, Caleb M. Wu, Jonn Thomas, Steven Clark, Haley |
author_facet | Sample, Caleb M. Wu, Jonn Thomas, Steven Clark, Haley |
author_sort | Sample, Caleb M. |
collection | PubMed |
description | Despite a great improvement in target volume dose conformality made possible in recent years by modulated therapies, xerostomia remains a common and severe side effect for head‐and‐neck radiotherapy patients. It is known that parotid glands exhibit a spatially varying dose response; however, the relative importance of subregions throughout the entire gland has yet to be incorporated into treatment plan optimization, with the current standard being to minimize the mean dose to whole parotid glands. The relative importance of regions within contralateral parotid glands has been recently quantified, creating an opportunity for the development of a method for including this data in plan optimization. We present a universal and straightforward approach for imposing varying sub‐parotid gland dose constraints during inverse treatment planning by using patient‐specific artificial base plans to penalize dose deposited in sensitive regions. In this work, the proposed method of optimization is demonstrated to reduce dose to regions of high relative importance throughout contralateral parotids and improve predictions for stimulated saliva output at 1‐year post‐radiotherapy. This method may also be applied to impose varying dose constraints to other organs‐at‐risk for which regional importance data exists. |
format | Online Article Text |
id | pubmed-7984464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79844642021-03-25 Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans Sample, Caleb M. Wu, Jonn Thomas, Steven Clark, Haley J Appl Clin Med Phys Radiation Oncology Physics Despite a great improvement in target volume dose conformality made possible in recent years by modulated therapies, xerostomia remains a common and severe side effect for head‐and‐neck radiotherapy patients. It is known that parotid glands exhibit a spatially varying dose response; however, the relative importance of subregions throughout the entire gland has yet to be incorporated into treatment plan optimization, with the current standard being to minimize the mean dose to whole parotid glands. The relative importance of regions within contralateral parotid glands has been recently quantified, creating an opportunity for the development of a method for including this data in plan optimization. We present a universal and straightforward approach for imposing varying sub‐parotid gland dose constraints during inverse treatment planning by using patient‐specific artificial base plans to penalize dose deposited in sensitive regions. In this work, the proposed method of optimization is demonstrated to reduce dose to regions of high relative importance throughout contralateral parotids and improve predictions for stimulated saliva output at 1‐year post‐radiotherapy. This method may also be applied to impose varying dose constraints to other organs‐at‐risk for which regional importance data exists. John Wiley and Sons Inc. 2021-02-09 /pmc/articles/PMC7984464/ /pubmed/33565210 http://dx.doi.org/10.1002/acm2.13192 Text en © 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of AmericanAssociation of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Sample, Caleb M. Wu, Jonn Thomas, Steven Clark, Haley Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title | Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title_full | Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title_fullStr | Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title_full_unstemmed | Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title_short | Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
title_sort | incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984464/ https://www.ncbi.nlm.nih.gov/pubmed/33565210 http://dx.doi.org/10.1002/acm2.13192 |
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