Cargando…

Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City

Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that is very common and causes a great burden in Saudi Arabia and worldwide. This study aims to determine the frequency and benefits of using hydroxyurea in treating children with SCD in King Abdulaziz University Hospita...

Descripción completa

Detalles Bibliográficos
Autores principales: Alzahrani, Fatma, Albaz, Ghaidaa F, AlSinan, Fatima, Alzuhayri, Jumana, Barnawi, Zahra M, Melebari, Nouf, Al Twairgi, Tethkar M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984494/
https://www.ncbi.nlm.nih.gov/pubmed/33767937
http://dx.doi.org/10.7759/cureus.13453
_version_ 1783668076688965632
author Alzahrani, Fatma
Albaz, Ghaidaa F
AlSinan, Fatima
Alzuhayri, Jumana
Barnawi, Zahra M
Melebari, Nouf
Al Twairgi, Tethkar M
author_facet Alzahrani, Fatma
Albaz, Ghaidaa F
AlSinan, Fatima
Alzuhayri, Jumana
Barnawi, Zahra M
Melebari, Nouf
Al Twairgi, Tethkar M
author_sort Alzahrani, Fatma
collection PubMed
description Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that is very common and causes a great burden in Saudi Arabia and worldwide. This study aims to determine the frequency and benefits of using hydroxyurea in treating children with SCD in King Abdulaziz University Hospital (KAUH) in Saudi Arabia. Method This retrospective observational study included all SCD patients, males and females, who were following up in KAUH and were less than 18 years old. Patients on chronic transfusion therapy or who had previous stem cell transplantation were excluded from the study. The study was approved by the unit of biomedical ethics in KAUH, Jeddah. Result The study included 102 SCD patients; the median age of the sample was 7.5±4.2, with the majority being female (58 patients; 56.9%). Hydroxyurea users among participants in the study were 62 patients (60.8%). Thirty-seven (37) of the patients using hydroxyurea had an increase in the mean corpuscular volume (MCV). There was a decrease in the level of white blood cells (WBCs) and neutrophil count from 15.81±10.24 and 48.31±23.23% to 12.48±5.48 and 40.81±15.78%, respectively. Platelet count showed an increase from 345.4±2.1096 to 359.162±199.87 after starting hydroxyurea. The incidence of vaso-occlusive crisis (VOC) increased after hydroxyurea initiation from 4.555±4.08 to 6.288±9.80. Moreover, the frequency of blood transfusion in patients using hydroxyurea was statistically significant as p-value = 0.048. Conclusion In conclusion, our results showed significant clinical and laboratory benefits of hydroxyurea in children with SCD. Hydroxyurea has been shown to reduce the frequency of VOC and blood transfusion in patients with SCD.
format Online
Article
Text
id pubmed-7984494
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-79844942021-03-24 Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City Alzahrani, Fatma Albaz, Ghaidaa F AlSinan, Fatima Alzuhayri, Jumana Barnawi, Zahra M Melebari, Nouf Al Twairgi, Tethkar M Cureus Pediatrics Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that is very common and causes a great burden in Saudi Arabia and worldwide. This study aims to determine the frequency and benefits of using hydroxyurea in treating children with SCD in King Abdulaziz University Hospital (KAUH) in Saudi Arabia. Method This retrospective observational study included all SCD patients, males and females, who were following up in KAUH and were less than 18 years old. Patients on chronic transfusion therapy or who had previous stem cell transplantation were excluded from the study. The study was approved by the unit of biomedical ethics in KAUH, Jeddah. Result The study included 102 SCD patients; the median age of the sample was 7.5±4.2, with the majority being female (58 patients; 56.9%). Hydroxyurea users among participants in the study were 62 patients (60.8%). Thirty-seven (37) of the patients using hydroxyurea had an increase in the mean corpuscular volume (MCV). There was a decrease in the level of white blood cells (WBCs) and neutrophil count from 15.81±10.24 and 48.31±23.23% to 12.48±5.48 and 40.81±15.78%, respectively. Platelet count showed an increase from 345.4±2.1096 to 359.162±199.87 after starting hydroxyurea. The incidence of vaso-occlusive crisis (VOC) increased after hydroxyurea initiation from 4.555±4.08 to 6.288±9.80. Moreover, the frequency of blood transfusion in patients using hydroxyurea was statistically significant as p-value = 0.048. Conclusion In conclusion, our results showed significant clinical and laboratory benefits of hydroxyurea in children with SCD. Hydroxyurea has been shown to reduce the frequency of VOC and blood transfusion in patients with SCD. Cureus 2021-02-20 /pmc/articles/PMC7984494/ /pubmed/33767937 http://dx.doi.org/10.7759/cureus.13453 Text en Copyright © 2021, Alzahrani et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Alzahrani, Fatma
Albaz, Ghaidaa F
AlSinan, Fatima
Alzuhayri, Jumana
Barnawi, Zahra M
Melebari, Nouf
Al Twairgi, Tethkar M
Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title_full Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title_fullStr Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title_full_unstemmed Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title_short Hydroxyurea Use Among Children With Sickle Cell Disease at King Abdulaziz University Hospital in Jeddah City
title_sort hydroxyurea use among children with sickle cell disease at king abdulaziz university hospital in jeddah city
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984494/
https://www.ncbi.nlm.nih.gov/pubmed/33767937
http://dx.doi.org/10.7759/cureus.13453
work_keys_str_mv AT alzahranifatma hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT albazghaidaaf hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT alsinanfatima hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT alzuhayrijumana hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT barnawizahram hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT melebarinouf hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity
AT altwairgitethkarm hydroxyureauseamongchildrenwithsicklecelldiseaseatkingabdulazizuniversityhospitalinjeddahcity