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Antibody kinetics and clinical course of COVID-19 a prospective observational study

BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over ti...

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Autores principales: Bläckberg, Anna, Fernström, Nils, Sarbrant, Emma, Rasmussen, Magnus, Sunnerhagen, Torgny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984607/
https://www.ncbi.nlm.nih.gov/pubmed/33750984
http://dx.doi.org/10.1371/journal.pone.0248918
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author Bläckberg, Anna
Fernström, Nils
Sarbrant, Emma
Rasmussen, Magnus
Sunnerhagen, Torgny
author_facet Bläckberg, Anna
Fernström, Nils
Sarbrant, Emma
Rasmussen, Magnus
Sunnerhagen, Torgny
author_sort Bläckberg, Anna
collection PubMed
description BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.
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spelling pubmed-79846072021-04-01 Antibody kinetics and clinical course of COVID-19 a prospective observational study Bläckberg, Anna Fernström, Nils Sarbrant, Emma Rasmussen, Magnus Sunnerhagen, Torgny PLoS One Research Article BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. Public Library of Science 2021-03-22 /pmc/articles/PMC7984607/ /pubmed/33750984 http://dx.doi.org/10.1371/journal.pone.0248918 Text en © 2021 Bläckberg et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bläckberg, Anna
Fernström, Nils
Sarbrant, Emma
Rasmussen, Magnus
Sunnerhagen, Torgny
Antibody kinetics and clinical course of COVID-19 a prospective observational study
title Antibody kinetics and clinical course of COVID-19 a prospective observational study
title_full Antibody kinetics and clinical course of COVID-19 a prospective observational study
title_fullStr Antibody kinetics and clinical course of COVID-19 a prospective observational study
title_full_unstemmed Antibody kinetics and clinical course of COVID-19 a prospective observational study
title_short Antibody kinetics and clinical course of COVID-19 a prospective observational study
title_sort antibody kinetics and clinical course of covid-19 a prospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984607/
https://www.ncbi.nlm.nih.gov/pubmed/33750984
http://dx.doi.org/10.1371/journal.pone.0248918
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