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Antibody kinetics and clinical course of COVID-19 a prospective observational study
BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over ti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984607/ https://www.ncbi.nlm.nih.gov/pubmed/33750984 http://dx.doi.org/10.1371/journal.pone.0248918 |
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author | Bläckberg, Anna Fernström, Nils Sarbrant, Emma Rasmussen, Magnus Sunnerhagen, Torgny |
author_facet | Bläckberg, Anna Fernström, Nils Sarbrant, Emma Rasmussen, Magnus Sunnerhagen, Torgny |
author_sort | Bläckberg, Anna |
collection | PubMed |
description | BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. |
format | Online Article Text |
id | pubmed-7984607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79846072021-04-01 Antibody kinetics and clinical course of COVID-19 a prospective observational study Bläckberg, Anna Fernström, Nils Sarbrant, Emma Rasmussen, Magnus Sunnerhagen, Torgny PLoS One Research Article BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. Public Library of Science 2021-03-22 /pmc/articles/PMC7984607/ /pubmed/33750984 http://dx.doi.org/10.1371/journal.pone.0248918 Text en © 2021 Bläckberg et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bläckberg, Anna Fernström, Nils Sarbrant, Emma Rasmussen, Magnus Sunnerhagen, Torgny Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title | Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title_full | Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title_fullStr | Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title_full_unstemmed | Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title_short | Antibody kinetics and clinical course of COVID-19 a prospective observational study |
title_sort | antibody kinetics and clinical course of covid-19 a prospective observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984607/ https://www.ncbi.nlm.nih.gov/pubmed/33750984 http://dx.doi.org/10.1371/journal.pone.0248918 |
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