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LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation

Pseudomonas aeruginosa causes chronic airway infections, a major determinant of lung inflammation and damage in cystic fibrosis (CF). Loss-of-function lasR mutants commonly arise during chronic CF infections, are associated with accelerated lung function decline in CF patients and induce exaggerated...

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Detalles Bibliográficos
Autores principales:	Hennemann, Lisa C., LaFayette, Shantelle L., Malet, Julien K., Bortolotti, Perrine, Yang, Tianxiao, McKay, Geoffrey A., Houle, Daniel, Radzioch, Danuta, Rousseau, Simon, Nguyen, Dao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984618/ https://www.ncbi.nlm.nih.gov/pubmed/33690714 http://dx.doi.org/10.1371/journal.ppat.1009375

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