N(6)-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages

N(6)-methyladenosine (m(6)A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions. RNA m(6)A modification is regulated by two groups of cellular proteins, writers and erasers that add or remove m(6)A, respectively. HIV-1 RNA contains m(6)A modificati...

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Detalles Bibliográficos
Autores principales: Chen, Shuliang, Kumar, Sameer, Espada, Constanza E., Tirumuru, Nagaraja, Cahill, Michael P., Hu, Lulu, He, Chuan, Wu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984636/
https://www.ncbi.nlm.nih.gov/pubmed/33690734
http://dx.doi.org/10.1371/journal.ppat.1009421

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