Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies

Pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer, has one of the highest case fatality rates of all known solid malignancies. Over the past decade, several landmark studies have established mutations in KRAS and TP53 as the predominant drivers of PDA...

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Detalles Bibliográficos
Autores principales: Kawalerski, Ryan R., Leach, Steven D., Escobar-Hoyos, Luisa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984828/
https://www.ncbi.nlm.nih.gov/pubmed/33796221
http://dx.doi.org/10.18632/oncotarget.27901

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