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Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System

Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus a...

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Detalles Bibliográficos
Autores principales: Zhou, Zijian, Qi, Dake, Gan, Quan, Wang, Fang, Qin, Bengang, Li, Jiachun, Wang, Honggang, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984887/
https://www.ncbi.nlm.nih.gov/pubmed/33791072
http://dx.doi.org/10.1155/2021/6657944
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author Zhou, Zijian
Qi, Dake
Gan, Quan
Wang, Fang
Qin, Bengang
Li, Jiachun
Wang, Honggang
Wang, Dong
author_facet Zhou, Zijian
Qi, Dake
Gan, Quan
Wang, Fang
Qin, Bengang
Li, Jiachun
Wang, Honggang
Wang, Dong
author_sort Zhou, Zijian
collection PubMed
description Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus affecting various physiological processes of the nervous system. In this review, we have compiled various reported lncRNAs related to the growth and development of central and peripheral nerves and pathophysiology (including advanced nerve centers, spinal cord, and peripheral nervous system) and explained how these lncRNAs play regulatory roles through their interactions with target-coding genes. We believe that a full understanding of the regulatory function of lncRNAs in the nervous system will contribute to understand the molecular mechanism of changes after nerve injury and will contribute to discover new diagnostic markers and therapeutic targets for nerve injury diseases.
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spelling pubmed-79848872021-03-30 Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System Zhou, Zijian Qi, Dake Gan, Quan Wang, Fang Qin, Bengang Li, Jiachun Wang, Honggang Wang, Dong Oxid Med Cell Longev Review Article Long noncoding RNAs (lncRNAs) have attracted extensive attention due to their regulatory role in various cellular processes. Emerging studies have indicated that lncRNAs are expressed to varying degrees after the growth and development of the nervous system as well as injury and degeneration, thus affecting various physiological processes of the nervous system. In this review, we have compiled various reported lncRNAs related to the growth and development of central and peripheral nerves and pathophysiology (including advanced nerve centers, spinal cord, and peripheral nervous system) and explained how these lncRNAs play regulatory roles through their interactions with target-coding genes. We believe that a full understanding of the regulatory function of lncRNAs in the nervous system will contribute to understand the molecular mechanism of changes after nerve injury and will contribute to discover new diagnostic markers and therapeutic targets for nerve injury diseases. Hindawi 2021-03-13 /pmc/articles/PMC7984887/ /pubmed/33791072 http://dx.doi.org/10.1155/2021/6657944 Text en Copyright © 2021 Zijian Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhou, Zijian
Qi, Dake
Gan, Quan
Wang, Fang
Qin, Bengang
Li, Jiachun
Wang, Honggang
Wang, Dong
Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title_full Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title_fullStr Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title_full_unstemmed Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title_short Studies on the Regulatory Roles and Related Mechanisms of lncRNAs in the Nervous System
title_sort studies on the regulatory roles and related mechanisms of lncrnas in the nervous system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984887/
https://www.ncbi.nlm.nih.gov/pubmed/33791072
http://dx.doi.org/10.1155/2021/6657944
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