Novel G1481V and Q1491H SCN5A Mutations Linked to Long QT Syndrome Destabilize the Nav1.5 Inactivation State

BACKGROUND: Na(v)1.5, which is encoded by the SCN5A gene, is the predominant voltage-gated Na(+) channel in the heart. Several mutations of this gene have been identified and reported to be involved in several cardiac rhythm disorders, including type 3 long QT interval syndrome, that can cause sudde...

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Detalles Bibliográficos
Autores principales: Plumereau, Quentin, Theriault, Olivier, Pouliot, Valérie, Moreau, Adrien, Morel, Elodie, Fressart, Véronique, Denjoy, Isabelle, Delinière, Antoine, Bessière, Francis, Chevalier, Philippe, Gamal El-Din, Tamer M., Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984979/
https://www.ncbi.nlm.nih.gov/pubmed/33778442
http://dx.doi.org/10.1016/j.cjco.2020.09.023

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