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Mechanisms of Action of Hypomethylating Agents: Endogenous Retroelements at the Epicenter

Abnormal DNA methylation patterns are thought to drive the pathobiology of high-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML). Sixteen years after their initial approval, the hypomethylating agents (HMAs), 5-azacytidine (AZA) and 5-aza-2′-deoxycytidine, remain the mainstay...

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Detalles Bibliográficos
Autores principales:	Kordella, Chryssoula, Lamprianidou, Eleftheria, Kotsianidis, Ioannis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985079/ https://www.ncbi.nlm.nih.gov/pubmed/33768008 http://dx.doi.org/10.3389/fonc.2021.650473

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