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Proteinuria as a Biomarker for COVID-19 Severity

BACKGROUND: Renal involvement in syndrome coronavirus 2 (SARS-CoV-2) infection has been retrospectively described, especially acute kidney injury (AKI). However, quantitative proteinuria assessment and its implication in coronavirus disease 2019 (COVID-19) remain unknown. METHODS: In this prospectiv...

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Autores principales: Ouahmi, Hajar, Courjon, Johan, Morand, Lucas, François, Juliette, Bruckert, Vincent, Lombardi, Romain, Esnault, Vincent, Seitz-Polski, Barbara, Demonchy, Elisa, Dellamonica, Jean, Boyer-Suavet, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985082/
https://www.ncbi.nlm.nih.gov/pubmed/33767630
http://dx.doi.org/10.3389/fphys.2021.611772
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author Ouahmi, Hajar
Courjon, Johan
Morand, Lucas
François, Juliette
Bruckert, Vincent
Lombardi, Romain
Esnault, Vincent
Seitz-Polski, Barbara
Demonchy, Elisa
Dellamonica, Jean
Boyer-Suavet, Sonia
author_facet Ouahmi, Hajar
Courjon, Johan
Morand, Lucas
François, Juliette
Bruckert, Vincent
Lombardi, Romain
Esnault, Vincent
Seitz-Polski, Barbara
Demonchy, Elisa
Dellamonica, Jean
Boyer-Suavet, Sonia
author_sort Ouahmi, Hajar
collection PubMed
description BACKGROUND: Renal involvement in syndrome coronavirus 2 (SARS-CoV-2) infection has been retrospectively described, especially acute kidney injury (AKI). However, quantitative proteinuria assessment and its implication in coronavirus disease 2019 (COVID-19) remain unknown. METHODS: In this prospective, multicenter study in France, we collected clinical and biological data including urinary protein to creatine ratio (UPCR) in patients presenting with moderate to severe COVID-19. Clinical outcome was analyzed according to the level of UPCR. RESULTS: 42/45 patients (93.3%) had renal involvement (abnormal urinary sediment and/or AKI). Significant proteinuria occurred in 60% of patients. Urine protein electrophoresis showed tubular protein excretion in 83.8% of patients with proteinuria. Inflammatory parametersand D-dimer concentrations correlated with proteinuria level. Patients who required intensive care unit (ICU) admission had higher proteinuria (p = 0.008). On multivariate analysis, proteinuria greater than 0.3 g/g was related to a higher prevalence of ICU admission [OR = 4.72, IC95 (1.16–23.21), p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 6.89, IC95 (1.41–53.01, p = 0.02)], nosocomial infections [OR = 3.75, IC95 (1.11–13.55), p = 0.03], longer inpatient hospital stay (p = 0.003). CONCLUSION: Renal involvement is common in moderate to severe SARS-CoV-2 infection. Proteinuria at baseline is an independent risk factor for increased hospitalization duration and ICU admission in patients with COVID-19.
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spelling pubmed-79850822021-03-24 Proteinuria as a Biomarker for COVID-19 Severity Ouahmi, Hajar Courjon, Johan Morand, Lucas François, Juliette Bruckert, Vincent Lombardi, Romain Esnault, Vincent Seitz-Polski, Barbara Demonchy, Elisa Dellamonica, Jean Boyer-Suavet, Sonia Front Physiol Physiology BACKGROUND: Renal involvement in syndrome coronavirus 2 (SARS-CoV-2) infection has been retrospectively described, especially acute kidney injury (AKI). However, quantitative proteinuria assessment and its implication in coronavirus disease 2019 (COVID-19) remain unknown. METHODS: In this prospective, multicenter study in France, we collected clinical and biological data including urinary protein to creatine ratio (UPCR) in patients presenting with moderate to severe COVID-19. Clinical outcome was analyzed according to the level of UPCR. RESULTS: 42/45 patients (93.3%) had renal involvement (abnormal urinary sediment and/or AKI). Significant proteinuria occurred in 60% of patients. Urine protein electrophoresis showed tubular protein excretion in 83.8% of patients with proteinuria. Inflammatory parametersand D-dimer concentrations correlated with proteinuria level. Patients who required intensive care unit (ICU) admission had higher proteinuria (p = 0.008). On multivariate analysis, proteinuria greater than 0.3 g/g was related to a higher prevalence of ICU admission [OR = 4.72, IC95 (1.16–23.21), p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 6.89, IC95 (1.41–53.01, p = 0.02)], nosocomial infections [OR = 3.75, IC95 (1.11–13.55), p = 0.03], longer inpatient hospital stay (p = 0.003). CONCLUSION: Renal involvement is common in moderate to severe SARS-CoV-2 infection. Proteinuria at baseline is an independent risk factor for increased hospitalization duration and ICU admission in patients with COVID-19. Frontiers Media S.A. 2021-03-09 /pmc/articles/PMC7985082/ /pubmed/33767630 http://dx.doi.org/10.3389/fphys.2021.611772 Text en Copyright © 2021 Ouahmi, Courjon, Morand, François, Bruckert, Lombardi, Esnault, Seitz-Polski, Demonchy, Dellamonica and Boyer-Suavet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ouahmi, Hajar
Courjon, Johan
Morand, Lucas
François, Juliette
Bruckert, Vincent
Lombardi, Romain
Esnault, Vincent
Seitz-Polski, Barbara
Demonchy, Elisa
Dellamonica, Jean
Boyer-Suavet, Sonia
Proteinuria as a Biomarker for COVID-19 Severity
title Proteinuria as a Biomarker for COVID-19 Severity
title_full Proteinuria as a Biomarker for COVID-19 Severity
title_fullStr Proteinuria as a Biomarker for COVID-19 Severity
title_full_unstemmed Proteinuria as a Biomarker for COVID-19 Severity
title_short Proteinuria as a Biomarker for COVID-19 Severity
title_sort proteinuria as a biomarker for covid-19 severity
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985082/
https://www.ncbi.nlm.nih.gov/pubmed/33767630
http://dx.doi.org/10.3389/fphys.2021.611772
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