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The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia

The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, i...

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Autores principales: Ghafouri-Fard, Soudeh, Abak, Atefe, Mohaqiq, Mahdi, Shoorei, Hamed, Taheri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985092/
https://www.ncbi.nlm.nih.gov/pubmed/33768092
http://dx.doi.org/10.3389/fcell.2021.634512
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author Ghafouri-Fard, Soudeh
Abak, Atefe
Mohaqiq, Mahdi
Shoorei, Hamed
Taheri, Mohammad
author_facet Ghafouri-Fard, Soudeh
Abak, Atefe
Mohaqiq, Mahdi
Shoorei, Hamed
Taheri, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities.
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spelling pubmed-79850922021-03-24 The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia Ghafouri-Fard, Soudeh Abak, Atefe Mohaqiq, Mahdi Shoorei, Hamed Taheri, Mohammad Front Cell Dev Biol Cell and Developmental Biology The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities. Frontiers Media S.A. 2021-03-09 /pmc/articles/PMC7985092/ /pubmed/33768092 http://dx.doi.org/10.3389/fcell.2021.634512 Text en Copyright © 2021 Ghafouri-Fard, Abak, Mohaqiq, Shoorei and Taheri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ghafouri-Fard, Soudeh
Abak, Atefe
Mohaqiq, Mahdi
Shoorei, Hamed
Taheri, Mohammad
The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title_full The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title_fullStr The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title_full_unstemmed The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title_short The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia
title_sort interplay between non-coding rnas and insulin-like growth factor signaling in the pathogenesis of neoplasia
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985092/
https://www.ncbi.nlm.nih.gov/pubmed/33768092
http://dx.doi.org/10.3389/fcell.2021.634512
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