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The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data

While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced B...

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Autores principales: Modi, Natansh D., Tan, Jin Quan Eugene, Rowland, Andrew, Koczwara, Bogda, Abuhelwa, Ahmad Y., Kichenadasse, Ganessan, McKinnon, Ross A., Wiese, Michael D., Sorich, Michael J., Hopkins, Ashley M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985140/
https://www.ncbi.nlm.nih.gov/pubmed/33753745
http://dx.doi.org/10.1038/s41523-021-00241-9
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author Modi, Natansh D.
Tan, Jin Quan Eugene
Rowland, Andrew
Koczwara, Bogda
Abuhelwa, Ahmad Y.
Kichenadasse, Ganessan
McKinnon, Ross A.
Wiese, Michael D.
Sorich, Michael J.
Hopkins, Ashley M.
author_facet Modi, Natansh D.
Tan, Jin Quan Eugene
Rowland, Andrew
Koczwara, Bogda
Abuhelwa, Ahmad Y.
Kichenadasse, Ganessan
McKinnon, Ross A.
Wiese, Michael D.
Sorich, Michael J.
Hopkins, Ashley M.
author_sort Modi, Natansh D.
collection PubMed
description While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13–1.51]; obese = 1.37 [1.14–1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98–1.24]; obese = 1.20 [1.04–1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76–0.96]; obese = 0.82 [0.72–0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83–1.01]; obese = 0.87 [0.77–0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.
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spelling pubmed-79851402021-04-12 The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data Modi, Natansh D. Tan, Jin Quan Eugene Rowland, Andrew Koczwara, Bogda Abuhelwa, Ahmad Y. Kichenadasse, Ganessan McKinnon, Ross A. Wiese, Michael D. Sorich, Michael J. Hopkins, Ashley M. NPJ Breast Cancer Article While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13–1.51]; obese = 1.37 [1.14–1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98–1.24]; obese = 1.20 [1.04–1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76–0.96]; obese = 0.82 [0.72–0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83–1.01]; obese = 0.87 [0.77–0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival. Nature Publishing Group UK 2021-03-22 /pmc/articles/PMC7985140/ /pubmed/33753745 http://dx.doi.org/10.1038/s41523-021-00241-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Modi, Natansh D.
Tan, Jin Quan Eugene
Rowland, Andrew
Koczwara, Bogda
Abuhelwa, Ahmad Y.
Kichenadasse, Ganessan
McKinnon, Ross A.
Wiese, Michael D.
Sorich, Michael J.
Hopkins, Ashley M.
The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_full The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_fullStr The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_full_unstemmed The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_short The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_sort obesity paradox in early and advanced her2 positive breast cancer: pooled analysis of clinical trial data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985140/
https://www.ncbi.nlm.nih.gov/pubmed/33753745
http://dx.doi.org/10.1038/s41523-021-00241-9
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