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A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients

The dysregulation of RNA binding proteins (RBPs) is closely related to tumorigenesis and development. However, the role of RBPs in Colon adenocarcinoma (COAD) is still poorly understood. We downloaded COAD’s RNASeq data from the Cancer Genome Atlas (TCGA) database, screened the differently expressed...

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Autores principales: Chang, Kaili, Yuan, Chong, Liu, Xueguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985171/
https://www.ncbi.nlm.nih.gov/pubmed/33767995
http://dx.doi.org/10.3389/fonc.2021.627504
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author Chang, Kaili
Yuan, Chong
Liu, Xueguang
author_facet Chang, Kaili
Yuan, Chong
Liu, Xueguang
author_sort Chang, Kaili
collection PubMed
description The dysregulation of RNA binding proteins (RBPs) is closely related to tumorigenesis and development. However, the role of RBPs in Colon adenocarcinoma (COAD) is still poorly understood. We downloaded COAD’s RNASeq data from the Cancer Genome Atlas (TCGA) database, screened the differently expressed RBPs in normal tissues and tumor, and constructed a protein interaction network. COAD patients were randomly divided into a training set (N = 315) and a testing set (N = 132). In the training set, univariate Cox analysis identified 12 RBPs significantly related to the prognosis of COAD. By multivariate COX analysis, we constructed a prognostic model composed of five RBPs (CELF4, LRRFIP2, NOP14, PPARGC1A, ZNF385A) based on the lowest Akaike information criterion. Each COAD patient was scored according to the model formula. Further analysis showed that compared with the low-risk group, the overall survival rate (OS) of patients in the high-risk group was significantly lower. The area under the curve of the time-dependent receiver operator characteristic (ROC) curve was 0.722 in the training group and 0.738 in the test group, which confirmed a good prediction feature. In addition, a nomogram was constructed based on clinicopathological characteristics and risk scores. C-index and calibration curve proved the accuracy in predicting the 1-, 3-, and 5-year survival rates of COAD patients. In short, we constructed a superior prognostic and diagnostic signature composed of five RBPs, which indicates new possibilities for individualized treatment of COAD patients.
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spelling pubmed-79851712021-03-24 A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients Chang, Kaili Yuan, Chong Liu, Xueguang Front Oncol Oncology The dysregulation of RNA binding proteins (RBPs) is closely related to tumorigenesis and development. However, the role of RBPs in Colon adenocarcinoma (COAD) is still poorly understood. We downloaded COAD’s RNASeq data from the Cancer Genome Atlas (TCGA) database, screened the differently expressed RBPs in normal tissues and tumor, and constructed a protein interaction network. COAD patients were randomly divided into a training set (N = 315) and a testing set (N = 132). In the training set, univariate Cox analysis identified 12 RBPs significantly related to the prognosis of COAD. By multivariate COX analysis, we constructed a prognostic model composed of five RBPs (CELF4, LRRFIP2, NOP14, PPARGC1A, ZNF385A) based on the lowest Akaike information criterion. Each COAD patient was scored according to the model formula. Further analysis showed that compared with the low-risk group, the overall survival rate (OS) of patients in the high-risk group was significantly lower. The area under the curve of the time-dependent receiver operator characteristic (ROC) curve was 0.722 in the training group and 0.738 in the test group, which confirmed a good prediction feature. In addition, a nomogram was constructed based on clinicopathological characteristics and risk scores. C-index and calibration curve proved the accuracy in predicting the 1-, 3-, and 5-year survival rates of COAD patients. In short, we constructed a superior prognostic and diagnostic signature composed of five RBPs, which indicates new possibilities for individualized treatment of COAD patients. Frontiers Media S.A. 2021-03-09 /pmc/articles/PMC7985171/ /pubmed/33767995 http://dx.doi.org/10.3389/fonc.2021.627504 Text en Copyright © 2021 Chang, Yuan and Liu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chang, Kaili
Yuan, Chong
Liu, Xueguang
A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title_full A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title_fullStr A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title_full_unstemmed A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title_short A New RBPs-Related Signature Predicts the Prognosis of Colon Adenocarcinoma Patients
title_sort new rbps-related signature predicts the prognosis of colon adenocarcinoma patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985171/
https://www.ncbi.nlm.nih.gov/pubmed/33767995
http://dx.doi.org/10.3389/fonc.2021.627504
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