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TMAO: a potential mediator of clopidogrel resistance
Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO. The p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985207/ https://www.ncbi.nlm.nih.gov/pubmed/33753834 http://dx.doi.org/10.1038/s41598-021-85950-8 |
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author | Ma, Ruisong Fu, Wenwen Zhang, Jing Hu, Xiaorong Yang, Jun Jiang, Hong |
author_facet | Ma, Ruisong Fu, Wenwen Zhang, Jing Hu, Xiaorong Yang, Jun Jiang, Hong |
author_sort | Ma, Ruisong |
collection | PubMed |
description | Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO. The present study aimed investigate the effects of TMAO on clopidogrel in ischemia and reperfusion (IR) model in rats. Clopidogrel could (1) promote the production of platelets, induce an increase in the platelet-larger cell ratio; (2) prolong the tail bleeding time; (3) reduce platelet aggregation function, induced by ADP, and alleviate myocardial thrombus burden. TMAO could partially offset the effects of clopidogrel and induce CR. Thus, the present study demonstrated that circulating TMAO could reduce the inhibitory effects of clopidogrel on platelet aggregation. TMAO may be a potential mediator of clopidogrel resistance. |
format | Online Article Text |
id | pubmed-7985207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79852072021-03-25 TMAO: a potential mediator of clopidogrel resistance Ma, Ruisong Fu, Wenwen Zhang, Jing Hu, Xiaorong Yang, Jun Jiang, Hong Sci Rep Article Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level. However, it remains unknown whether Clopidogrel Resistance (CR) could be attributed to TMAO. The present study aimed investigate the effects of TMAO on clopidogrel in ischemia and reperfusion (IR) model in rats. Clopidogrel could (1) promote the production of platelets, induce an increase in the platelet-larger cell ratio; (2) prolong the tail bleeding time; (3) reduce platelet aggregation function, induced by ADP, and alleviate myocardial thrombus burden. TMAO could partially offset the effects of clopidogrel and induce CR. Thus, the present study demonstrated that circulating TMAO could reduce the inhibitory effects of clopidogrel on platelet aggregation. TMAO may be a potential mediator of clopidogrel resistance. Nature Publishing Group UK 2021-03-22 /pmc/articles/PMC7985207/ /pubmed/33753834 http://dx.doi.org/10.1038/s41598-021-85950-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ma, Ruisong Fu, Wenwen Zhang, Jing Hu, Xiaorong Yang, Jun Jiang, Hong TMAO: a potential mediator of clopidogrel resistance |
title | TMAO: a potential mediator of clopidogrel resistance |
title_full | TMAO: a potential mediator of clopidogrel resistance |
title_fullStr | TMAO: a potential mediator of clopidogrel resistance |
title_full_unstemmed | TMAO: a potential mediator of clopidogrel resistance |
title_short | TMAO: a potential mediator of clopidogrel resistance |
title_sort | tmao: a potential mediator of clopidogrel resistance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985207/ https://www.ncbi.nlm.nih.gov/pubmed/33753834 http://dx.doi.org/10.1038/s41598-021-85950-8 |
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