Structural insights into SARS-CoV-2 infection and therapeutics development

The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV...

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Autores principales: Sun, Gangyu, Xue, Lulu, He, Qingjing, Zhao, Yue, Xu, Wenqing, Wang, Zhizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985237/
https://www.ncbi.nlm.nih.gov/pubmed/33550140
http://dx.doi.org/10.1016/j.scr.2021.102219
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author Sun, Gangyu
Xue, Lulu
He, Qingjing
Zhao, Yue
Xu, Wenqing
Wang, Zhizhi
author_facet Sun, Gangyu
Xue, Lulu
He, Qingjing
Zhao, Yue
Xu, Wenqing
Wang, Zhizhi
author_sort Sun, Gangyu
collection PubMed
description The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19.
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spelling pubmed-79852372021-03-23 Structural insights into SARS-CoV-2 infection and therapeutics development Sun, Gangyu Xue, Lulu He, Qingjing Zhao, Yue Xu, Wenqing Wang, Zhizhi Stem Cell Res Article The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19. The Author(s). Published by Elsevier B.V. 2021-04 2021-02-02 /pmc/articles/PMC7985237/ /pubmed/33550140 http://dx.doi.org/10.1016/j.scr.2021.102219 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sun, Gangyu
Xue, Lulu
He, Qingjing
Zhao, Yue
Xu, Wenqing
Wang, Zhizhi
Structural insights into SARS-CoV-2 infection and therapeutics development
title Structural insights into SARS-CoV-2 infection and therapeutics development
title_full Structural insights into SARS-CoV-2 infection and therapeutics development
title_fullStr Structural insights into SARS-CoV-2 infection and therapeutics development
title_full_unstemmed Structural insights into SARS-CoV-2 infection and therapeutics development
title_short Structural insights into SARS-CoV-2 infection and therapeutics development
title_sort structural insights into sars-cov-2 infection and therapeutics development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985237/
https://www.ncbi.nlm.nih.gov/pubmed/33550140
http://dx.doi.org/10.1016/j.scr.2021.102219
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