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Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health

BACKGROUND: Little is known about the interplay among dairy intake, gut microbiota and cardiometabolic health in human prospective cohort studies. METHODS: The present study included 1780 participants from the Guangzhou Nutrition and Health Study. We examined the prospective association between habi...

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Autores principales: Shuai, Menglei, Zuo, Luo-Shi-Yuan, Miao, Zelei, Gou, Wanglong, Xu, Fengzhe, Jiang, Zengliang, Ling, Chu-wen, Fu, Yuanqing, Xiong, Feng, Chen, Yu-ming, Zheng, Ju-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985282/
https://www.ncbi.nlm.nih.gov/pubmed/33752125
http://dx.doi.org/10.1016/j.ebiom.2021.103284
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author Shuai, Menglei
Zuo, Luo-Shi-Yuan
Miao, Zelei
Gou, Wanglong
Xu, Fengzhe
Jiang, Zengliang
Ling, Chu-wen
Fu, Yuanqing
Xiong, Feng
Chen, Yu-ming
Zheng, Ju-Sheng
author_facet Shuai, Menglei
Zuo, Luo-Shi-Yuan
Miao, Zelei
Gou, Wanglong
Xu, Fengzhe
Jiang, Zengliang
Ling, Chu-wen
Fu, Yuanqing
Xiong, Feng
Chen, Yu-ming
Zheng, Ju-Sheng
author_sort Shuai, Menglei
collection PubMed
description BACKGROUND: Little is known about the interplay among dairy intake, gut microbiota and cardiometabolic health in human prospective cohort studies. METHODS: The present study included 1780 participants from the Guangzhou Nutrition and Health Study. We examined the prospective association between habitual dairy consumption (total dairy, milk, yogurt) and gut microbial composition using linear regression after adjusting for socio-demographic, lifestyle and dietary factors. The cross-sectional association of dairy-associated microbial features with cardiometabolic risk factors was examined with a linear regression model, adjusting for potential confounders. Serum metabolomic profiles were analyzed by partial correlation analysis. FINDINGS: There was a significant overall difference in gut microbial community structure (β-diversity) comparing the highest with the lowest category for each of total dairy, milk and yogurt (P < 0.05). We observed that dairy-associated microbes and α-diversity indices were inversely associated with blood triglycerides, while positively associated with high-density lipoprotein cholesterol. A follow-up metabolomics analysis revealed the association of targeted serum metabolites with dairy-microbial features and cardiometabolic traits. Specifically, 2-hydroxy-3-methylbutyric acid, 2-hydroxybutyric acid and L-alanine were inversely associated with dairy-microbial score, while positively associated with triglycerides (FDR-corrected P < 0.1). INTERPRETATION: Dairy consumption is associated with the gut microbial composition and a higher α-diversity, which provides new insights into the understanding of dairy-gut microbiota interactions and their relationship with cardiometabolic health. FUNDING: This work was supported by the National Natural Science Foundation of China, Zhejiang Ten-thousand Talents Program, Westlake University and the 5010 Program for Clinical Researches of the Sun Yat-sen University.
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spelling pubmed-79852822021-03-25 Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health Shuai, Menglei Zuo, Luo-Shi-Yuan Miao, Zelei Gou, Wanglong Xu, Fengzhe Jiang, Zengliang Ling, Chu-wen Fu, Yuanqing Xiong, Feng Chen, Yu-ming Zheng, Ju-Sheng EBioMedicine Research paper BACKGROUND: Little is known about the interplay among dairy intake, gut microbiota and cardiometabolic health in human prospective cohort studies. METHODS: The present study included 1780 participants from the Guangzhou Nutrition and Health Study. We examined the prospective association between habitual dairy consumption (total dairy, milk, yogurt) and gut microbial composition using linear regression after adjusting for socio-demographic, lifestyle and dietary factors. The cross-sectional association of dairy-associated microbial features with cardiometabolic risk factors was examined with a linear regression model, adjusting for potential confounders. Serum metabolomic profiles were analyzed by partial correlation analysis. FINDINGS: There was a significant overall difference in gut microbial community structure (β-diversity) comparing the highest with the lowest category for each of total dairy, milk and yogurt (P < 0.05). We observed that dairy-associated microbes and α-diversity indices were inversely associated with blood triglycerides, while positively associated with high-density lipoprotein cholesterol. A follow-up metabolomics analysis revealed the association of targeted serum metabolites with dairy-microbial features and cardiometabolic traits. Specifically, 2-hydroxy-3-methylbutyric acid, 2-hydroxybutyric acid and L-alanine were inversely associated with dairy-microbial score, while positively associated with triglycerides (FDR-corrected P < 0.1). INTERPRETATION: Dairy consumption is associated with the gut microbial composition and a higher α-diversity, which provides new insights into the understanding of dairy-gut microbiota interactions and their relationship with cardiometabolic health. FUNDING: This work was supported by the National Natural Science Foundation of China, Zhejiang Ten-thousand Talents Program, Westlake University and the 5010 Program for Clinical Researches of the Sun Yat-sen University. Elsevier 2021-03-19 /pmc/articles/PMC7985282/ /pubmed/33752125 http://dx.doi.org/10.1016/j.ebiom.2021.103284 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research paper
Shuai, Menglei
Zuo, Luo-Shi-Yuan
Miao, Zelei
Gou, Wanglong
Xu, Fengzhe
Jiang, Zengliang
Ling, Chu-wen
Fu, Yuanqing
Xiong, Feng
Chen, Yu-ming
Zheng, Ju-Sheng
Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title_full Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title_fullStr Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title_full_unstemmed Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title_short Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
title_sort multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health
topic Research paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985282/
https://www.ncbi.nlm.nih.gov/pubmed/33752125
http://dx.doi.org/10.1016/j.ebiom.2021.103284
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