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The Tree Shrew as a Model for Cancer Research

Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer. The most important thing in the selection of animal models is to consider the similarity between animals and humans. The tree shrew...

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Autores principales: Lu, Tao, Peng, Hongmei, Zhong, Liping, Wu, Pan, He, Jian, Deng, Zhiming, Huang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985444/
https://www.ncbi.nlm.nih.gov/pubmed/33768009
http://dx.doi.org/10.3389/fonc.2021.653236
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author Lu, Tao
Peng, Hongmei
Zhong, Liping
Wu, Pan
He, Jian
Deng, Zhiming
Huang, Yong
author_facet Lu, Tao
Peng, Hongmei
Zhong, Liping
Wu, Pan
He, Jian
Deng, Zhiming
Huang, Yong
author_sort Lu, Tao
collection PubMed
description Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer. The most important thing in the selection of animal models is to consider the similarity between animals and humans. The tree shrew (Tupaia belangeri) is a squirrel-like mammal which placed in the order Scandentia. Whole-genome sequencing has revealed that tree shrews are extremely similar to primate and humans than to rodents, with many highly conserved genes, which makes the data from studies that use tree shrews as models more convincing and the research outcomes more easily translatable. In tumor research, tree shrews are often used as animal models for hepatic and mammary cancers. As research has progressed, other types of tree shrew tumor models have been developed and exhibit clinical manifestations similar to those of humans. Combining the advantages of both rodents and primates, the tree shrew is expected to be the most powerful animal model for studying tumors.
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spelling pubmed-79854442021-03-24 The Tree Shrew as a Model for Cancer Research Lu, Tao Peng, Hongmei Zhong, Liping Wu, Pan He, Jian Deng, Zhiming Huang, Yong Front Oncol Oncology Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer. The most important thing in the selection of animal models is to consider the similarity between animals and humans. The tree shrew (Tupaia belangeri) is a squirrel-like mammal which placed in the order Scandentia. Whole-genome sequencing has revealed that tree shrews are extremely similar to primate and humans than to rodents, with many highly conserved genes, which makes the data from studies that use tree shrews as models more convincing and the research outcomes more easily translatable. In tumor research, tree shrews are often used as animal models for hepatic and mammary cancers. As research has progressed, other types of tree shrew tumor models have been developed and exhibit clinical manifestations similar to those of humans. Combining the advantages of both rodents and primates, the tree shrew is expected to be the most powerful animal model for studying tumors. Frontiers Media S.A. 2021-03-09 /pmc/articles/PMC7985444/ /pubmed/33768009 http://dx.doi.org/10.3389/fonc.2021.653236 Text en Copyright © 2021 Lu, Peng, Zhong, Wu, He, Deng and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lu, Tao
Peng, Hongmei
Zhong, Liping
Wu, Pan
He, Jian
Deng, Zhiming
Huang, Yong
The Tree Shrew as a Model for Cancer Research
title The Tree Shrew as a Model for Cancer Research
title_full The Tree Shrew as a Model for Cancer Research
title_fullStr The Tree Shrew as a Model for Cancer Research
title_full_unstemmed The Tree Shrew as a Model for Cancer Research
title_short The Tree Shrew as a Model for Cancer Research
title_sort tree shrew as a model for cancer research
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985444/
https://www.ncbi.nlm.nih.gov/pubmed/33768009
http://dx.doi.org/10.3389/fonc.2021.653236
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