Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma

Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand-independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation...

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Detalles Bibliográficos
Autores principales: Kubo, Hiroshi, Yagyu, Shigeki, Nakamura, Kayoko, Yamashima, Kumiko, Tomida, Akimasa, Kikuchi, Ken, Iehara, Tomoko, Nakazawa, Yozo, Hosoi, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985479/
https://www.ncbi.nlm.nih.gov/pubmed/33816783
http://dx.doi.org/10.1016/j.omto.2021.03.001

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