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Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles

This study was aimed at estimating the intake of lead and cadmium by the Belgian consumers due to the use of ceramic ware. We adopted refined exposure scenarios with respect to migrant concentration, ceramic ware usage, and metal release characteristics. A deterministic estimation was initially perf...

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Detalles Bibliográficos
Autores principales: Li, Yan, Zhang, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985700/
https://www.ncbi.nlm.nih.gov/pubmed/33777701
http://dx.doi.org/10.1016/j.toxrep.2021.02.015
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author Li, Yan
Zhang, Jianqing
author_facet Li, Yan
Zhang, Jianqing
author_sort Li, Yan
collection PubMed
description This study was aimed at estimating the intake of lead and cadmium by the Belgian consumers due to the use of ceramic ware. We adopted refined exposure scenarios with respect to migrant concentration, ceramic ware usage, and metal release characteristics. A deterministic estimation was initially performed, followed by probabilistic estimation, if the deterministic estimate exceeds toxicological reference values. Based on the reference doses established by the European Food Safety Authority (EFSA), the risk of lead and cadmium exposure was characterized by the margin of exposure (MOE) and the tolerable weekly intake (TWI), respectively. The probabilistic median and 95th percentile intake of lead were 0.02 and 5.77 μg/kg b.w. per day for adults, and 0.07 and 17.3 μg/kg b.w. per day for children. The MOEs for neurotoxicity, nephrotoxicity and cardiovascular effects were 7.1, 27 and 64 for average consumers, and 0.02, 0.1 and 0.3 for high consumers. The deterministic mean and 95th percentile intake of cadmium were 0.026 (7% TWI) and 0.03 (8% TWI) μg/kg b.w. per day for adults, and 0.08 (22 % TWI) and 0.09 (25 % TWI) μg/kg b.w. per day for children. Considering the exposure of the Belgian population from foodstuffs resulted in the exceedance of the TWI by as much as 20-fold. The risk of exposure to lead and cadmium of the Belgian consumers suggests measures, such as lowering the migration limits for ceramic ware, should be taken to minimize the risk.
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spelling pubmed-79857002021-03-25 Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles Li, Yan Zhang, Jianqing Toxicol Rep Regular Article This study was aimed at estimating the intake of lead and cadmium by the Belgian consumers due to the use of ceramic ware. We adopted refined exposure scenarios with respect to migrant concentration, ceramic ware usage, and metal release characteristics. A deterministic estimation was initially performed, followed by probabilistic estimation, if the deterministic estimate exceeds toxicological reference values. Based on the reference doses established by the European Food Safety Authority (EFSA), the risk of lead and cadmium exposure was characterized by the margin of exposure (MOE) and the tolerable weekly intake (TWI), respectively. The probabilistic median and 95th percentile intake of lead were 0.02 and 5.77 μg/kg b.w. per day for adults, and 0.07 and 17.3 μg/kg b.w. per day for children. The MOEs for neurotoxicity, nephrotoxicity and cardiovascular effects were 7.1, 27 and 64 for average consumers, and 0.02, 0.1 and 0.3 for high consumers. The deterministic mean and 95th percentile intake of cadmium were 0.026 (7% TWI) and 0.03 (8% TWI) μg/kg b.w. per day for adults, and 0.08 (22 % TWI) and 0.09 (25 % TWI) μg/kg b.w. per day for children. Considering the exposure of the Belgian population from foodstuffs resulted in the exceedance of the TWI by as much as 20-fold. The risk of exposure to lead and cadmium of the Belgian consumers suggests measures, such as lowering the migration limits for ceramic ware, should be taken to minimize the risk. Elsevier 2021-02-23 /pmc/articles/PMC7985700/ /pubmed/33777701 http://dx.doi.org/10.1016/j.toxrep.2021.02.015 Text en © 2021 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Li, Yan
Zhang, Jianqing
Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title_full Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title_fullStr Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title_full_unstemmed Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title_short Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles
title_sort exposure to lead and cadmium of the belgian consumers from ceramic food contact articles
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985700/
https://www.ncbi.nlm.nih.gov/pubmed/33777701
http://dx.doi.org/10.1016/j.toxrep.2021.02.015
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