Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas

A series of 1,3-disubstituted ureas containing a lipophilic adamantane moiety tethered to the ureido group by a methylene bridge were synthesized by the reaction of 1-(isocyanatomethyl)adamantane with monohalo- and dihaloanilines in yields of up to 92%. The synthesized ureas are target oriented inhi...

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Autores principales: Danilov, D. V., D’yachenko, V. S., Kuznetsov, Y. P., Burmistrov, V. V., Butov, G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985748/
http://dx.doi.org/10.1134/S1070428021020020
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author Danilov, D. V.
D’yachenko, V. S.
Kuznetsov, Y. P.
Burmistrov, V. V.
Butov, G. M.
author_facet Danilov, D. V.
D’yachenko, V. S.
Kuznetsov, Y. P.
Burmistrov, V. V.
Butov, G. M.
author_sort Danilov, D. V.
collection PubMed
description A series of 1,3-disubstituted ureas containing a lipophilic adamantane moiety tethered to the ureido group by a methylene bridge were synthesized by the reaction of 1-(isocyanatomethyl)adamantane with monohalo- and dihaloanilines in yields of up to 92%. The synthesized ureas are target oriented inhibitors of human soluble epoxide hydrolase (sEH).
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spelling pubmed-79857482021-03-23 Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas Danilov, D. V. D’yachenko, V. S. Kuznetsov, Y. P. Burmistrov, V. V. Butov, G. M. Russ J Org Chem Article A series of 1,3-disubstituted ureas containing a lipophilic adamantane moiety tethered to the ureido group by a methylene bridge were synthesized by the reaction of 1-(isocyanatomethyl)adamantane with monohalo- and dihaloanilines in yields of up to 92%. The synthesized ureas are target oriented inhibitors of human soluble epoxide hydrolase (sEH). Pleiades Publishing 2021-03-23 2021 /pmc/articles/PMC7985748/ http://dx.doi.org/10.1134/S1070428021020020 Text en © Pleiades Publishing, Ltd. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Danilov, D. V.
D’yachenko, V. S.
Kuznetsov, Y. P.
Burmistrov, V. V.
Butov, G. M.
Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title_full Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title_fullStr Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title_full_unstemmed Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title_short Synthesis and Properties of 1,3-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VII. Synthesis and Properties 1-[(Adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) Ureas
title_sort synthesis and properties of 1,3-disubstituted ureas and their isosteric analogs containing polycyclic fragments: vii. synthesis and properties 1-[(adamantan-1-yl)methyl]-3-(fluoro, chlorophenyl) ureas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985748/
http://dx.doi.org/10.1134/S1070428021020020
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