Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists

Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunatel...

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Detalles Bibliográficos
Autores principales: Uchiyama, Angel A. T., Silva, Pedro A. I. A., Lopes, Moisés S. M., Yen, Cheng T., Ricardo, Eliza D., Mutão, Taciana, Pimenta, Jefferson R., Machado, Larissa M., Shimba, Denis S., Peixoto, Renata D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985775/
https://www.ncbi.nlm.nih.gov/pubmed/33546228
http://dx.doi.org/10.3390/curroncol28010076
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author Uchiyama, Angel A. T.
Silva, Pedro A. I. A.
Lopes, Moisés S. M.
Yen, Cheng T.
Ricardo, Eliza D.
Mutão, Taciana
Pimenta, Jefferson R.
Machado, Larissa M.
Shimba, Denis S.
Peixoto, Renata D.
author_facet Uchiyama, Angel A. T.
Silva, Pedro A. I. A.
Lopes, Moisés S. M.
Yen, Cheng T.
Ricardo, Eliza D.
Mutão, Taciana
Pimenta, Jefferson R.
Machado, Larissa M.
Shimba, Denis S.
Peixoto, Renata D.
author_sort Uchiyama, Angel A. T.
collection PubMed
description Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents. We aim at reviewing current evidence on this possible interaction by dividing anti-cancer agents by class. Until further data is available, we encourage healthcare providers to limit unnecessary PPI overuse.
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spelling pubmed-79857752021-03-24 Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists Uchiyama, Angel A. T. Silva, Pedro A. I. A. Lopes, Moisés S. M. Yen, Cheng T. Ricardo, Eliza D. Mutão, Taciana Pimenta, Jefferson R. Machado, Larissa M. Shimba, Denis S. Peixoto, Renata D. Curr Oncol Review Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents. We aim at reviewing current evidence on this possible interaction by dividing anti-cancer agents by class. Until further data is available, we encourage healthcare providers to limit unnecessary PPI overuse. MDPI 2021-02-03 /pmc/articles/PMC7985775/ /pubmed/33546228 http://dx.doi.org/10.3390/curroncol28010076 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Uchiyama, Angel A. T.
Silva, Pedro A. I. A.
Lopes, Moisés S. M.
Yen, Cheng T.
Ricardo, Eliza D.
Mutão, Taciana
Pimenta, Jefferson R.
Machado, Larissa M.
Shimba, Denis S.
Peixoto, Renata D.
Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title_full Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title_fullStr Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title_full_unstemmed Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title_short Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists
title_sort proton pump inhibitors and oncologic treatment efficacy: a practical review of the literature for oncologists
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985775/
https://www.ncbi.nlm.nih.gov/pubmed/33546228
http://dx.doi.org/10.3390/curroncol28010076
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