Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly

The electrochemical three‐component assembly of isoquinolines has been accomplished by ruthenaelectro‐catalyzed C−H/N−H functionalization. The robustness of the electrocatalysis was reflected by an ample substrate scope, an efficient electrooxidation, and an operationally friendly procedure. The iso...

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Autores principales: Tan, Xuefeng, Hou, Xiaoyan, Rogge, Torben, Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985882/
https://www.ncbi.nlm.nih.gov/pubmed/33270973
http://dx.doi.org/10.1002/anie.202014289
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author Tan, Xuefeng
Hou, Xiaoyan
Rogge, Torben
Ackermann, Lutz
author_facet Tan, Xuefeng
Hou, Xiaoyan
Rogge, Torben
Ackermann, Lutz
author_sort Tan, Xuefeng
collection PubMed
description The electrochemical three‐component assembly of isoquinolines has been accomplished by ruthenaelectro‐catalyzed C−H/N−H functionalization. The robustness of the electrocatalysis was reflected by an ample substrate scope, an efficient electrooxidation, and an operationally friendly procedure. The isolation of key intermediates and detailed mechanistic studies, including unprecedented cyclovoltammetric analysis of a seven‐membered ruthenacycle, provided support for an unusual ruthenium(II/III/I) regime.
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spelling pubmed-79858822021-03-25 Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly Tan, Xuefeng Hou, Xiaoyan Rogge, Torben Ackermann, Lutz Angew Chem Int Ed Engl Communications The electrochemical three‐component assembly of isoquinolines has been accomplished by ruthenaelectro‐catalyzed C−H/N−H functionalization. The robustness of the electrocatalysis was reflected by an ample substrate scope, an efficient electrooxidation, and an operationally friendly procedure. The isolation of key intermediates and detailed mechanistic studies, including unprecedented cyclovoltammetric analysis of a seven‐membered ruthenacycle, provided support for an unusual ruthenium(II/III/I) regime. John Wiley and Sons Inc. 2021-01-18 2021-02-23 /pmc/articles/PMC7985882/ /pubmed/33270973 http://dx.doi.org/10.1002/anie.202014289 Text en © 2020 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Tan, Xuefeng
Hou, Xiaoyan
Rogge, Torben
Ackermann, Lutz
Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title_full Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title_fullStr Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title_full_unstemmed Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title_short Ruthenaelectro‐Catalyzed Domino Three‐Component Alkyne Annulation for Expedient Isoquinoline Assembly
title_sort ruthenaelectro‐catalyzed domino three‐component alkyne annulation for expedient isoquinoline assembly
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985882/
https://www.ncbi.nlm.nih.gov/pubmed/33270973
http://dx.doi.org/10.1002/anie.202014289
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AT houxiaoyan ruthenaelectrocatalyzeddominothreecomponentalkyneannulationforexpedientisoquinolineassembly
AT roggetorben ruthenaelectrocatalyzeddominothreecomponentalkyneannulationforexpedientisoquinolineassembly
AT ackermannlutz ruthenaelectrocatalyzeddominothreecomponentalkyneannulationforexpedientisoquinolineassembly

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