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Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis
Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in HF. The interaction between HSCs and surrounding cells is also cruc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986015/ https://www.ncbi.nlm.nih.gov/pubmed/33760176 http://dx.doi.org/10.3892/mmr.2021.12003 |
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author | Cheng, Qi-Ni Yang, Xue Wu, Jiang-Feng Ai, Wen-Bing Ni, Yi-Ran |
author_facet | Cheng, Qi-Ni Yang, Xue Wu, Jiang-Feng Ai, Wen-Bing Ni, Yi-Ran |
author_sort | Cheng, Qi-Ni |
collection | PubMed |
description | Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in HF. The interaction between HSCs and surrounding cells is also crucial. Additionally, hepatic sinusoids capillarization, inflammation, angiogenesis and fibrosis develop during HF. The process involves multiple cell types that are highly connected and work in unison to maintain the homeostasis of the hepatic microenvironment, which serves a key role in the initiation and progression of HF. The current review provides novel insight into the intercellular interaction among liver sinusoidal endothelial cells, HSCs and Kupffer cells, as well as the hepatic microenvironment in the development of HF. |
format | Online Article Text |
id | pubmed-7986015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-79860152021-03-26 Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis Cheng, Qi-Ni Yang, Xue Wu, Jiang-Feng Ai, Wen-Bing Ni, Yi-Ran Mol Med Rep Review Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in HF. The interaction between HSCs and surrounding cells is also crucial. Additionally, hepatic sinusoids capillarization, inflammation, angiogenesis and fibrosis develop during HF. The process involves multiple cell types that are highly connected and work in unison to maintain the homeostasis of the hepatic microenvironment, which serves a key role in the initiation and progression of HF. The current review provides novel insight into the intercellular interaction among liver sinusoidal endothelial cells, HSCs and Kupffer cells, as well as the hepatic microenvironment in the development of HF. D.A. Spandidos 2021-05 2021-03-16 /pmc/articles/PMC7986015/ /pubmed/33760176 http://dx.doi.org/10.3892/mmr.2021.12003 Text en Copyright: © Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Cheng, Qi-Ni Yang, Xue Wu, Jiang-Feng Ai, Wen-Bing Ni, Yi-Ran Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title | Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title_full | Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title_fullStr | Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title_full_unstemmed | Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title_short | Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
title_sort | interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986015/ https://www.ncbi.nlm.nih.gov/pubmed/33760176 http://dx.doi.org/10.3892/mmr.2021.12003 |
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