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Platinum accumulation in oxaliplatin‐induced peripheral neuropathy

Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common and dose‐limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation...

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Autores principales: Wei, Guoli, Gu, Zhancheng, Gu, Jialin, Yu, Jialin, Huang, Xiaofei, Qin, Fengxia, Li, Lingchang, Ding, Rong, Huo, Jiege
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986112/
https://www.ncbi.nlm.nih.gov/pubmed/33462873
http://dx.doi.org/10.1111/jns.12432
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author Wei, Guoli
Gu, Zhancheng
Gu, Jialin
Yu, Jialin
Huang, Xiaofei
Qin, Fengxia
Li, Lingchang
Ding, Rong
Huo, Jiege
author_facet Wei, Guoli
Gu, Zhancheng
Gu, Jialin
Yu, Jialin
Huang, Xiaofei
Qin, Fengxia
Li, Lingchang
Ding, Rong
Huo, Jiege
author_sort Wei, Guoli
collection PubMed
description Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common and dose‐limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation in peripheral nervous system, especially in dorsal root ganglion, is a significant mechanism of OIPN. Several specific transporters, including organic cation transporters, high‐affinity copper uptake protein1 (CTR1), ATPase copper transporting alpha (ATP7A) and multidrug and toxin extrusion protein 1 (MATE1), could be associated with this mechanism. This review summarizes the current research progress about the relationship between platinum accumulation and OIPN, as well as suggests trend for the future research.
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spelling pubmed-79861122021-03-25 Platinum accumulation in oxaliplatin‐induced peripheral neuropathy Wei, Guoli Gu, Zhancheng Gu, Jialin Yu, Jialin Huang, Xiaofei Qin, Fengxia Li, Lingchang Ding, Rong Huo, Jiege J Peripher Nerv Syst Reviews Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common and dose‐limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation in peripheral nervous system, especially in dorsal root ganglion, is a significant mechanism of OIPN. Several specific transporters, including organic cation transporters, high‐affinity copper uptake protein1 (CTR1), ATPase copper transporting alpha (ATP7A) and multidrug and toxin extrusion protein 1 (MATE1), could be associated with this mechanism. This review summarizes the current research progress about the relationship between platinum accumulation and OIPN, as well as suggests trend for the future research. Wiley Periodicals, Inc. 2021-01-27 2021-03 /pmc/articles/PMC7986112/ /pubmed/33462873 http://dx.doi.org/10.1111/jns.12432 Text en © 2021 The Authors. Journal of the Peripheral Nervous System published by Wiley Periodicals LLC on behalf of Peripheral Nerve Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Wei, Guoli
Gu, Zhancheng
Gu, Jialin
Yu, Jialin
Huang, Xiaofei
Qin, Fengxia
Li, Lingchang
Ding, Rong
Huo, Jiege
Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title_full Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title_fullStr Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title_full_unstemmed Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title_short Platinum accumulation in oxaliplatin‐induced peripheral neuropathy
title_sort platinum accumulation in oxaliplatin‐induced peripheral neuropathy
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986112/
https://www.ncbi.nlm.nih.gov/pubmed/33462873
http://dx.doi.org/10.1111/jns.12432
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