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The IS6 family, a clinically important group of insertion sequences including IS26
The IS6 family of bacterial and archaeal insertion sequences, first identified in the early 1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic resistance. Two IS, IS26 (found in many enterobacterial clinical isolates as components of both chromosome and plasm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986276/ https://www.ncbi.nlm.nih.gov/pubmed/33757578 http://dx.doi.org/10.1186/s13100-021-00239-x |
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author | Varani, Alessandro He, Susu Siguier, Patricia Ross, Karen Chandler, Michael |
author_facet | Varani, Alessandro He, Susu Siguier, Patricia Ross, Karen Chandler, Michael |
author_sort | Varani, Alessandro |
collection | PubMed |
description | The IS6 family of bacterial and archaeal insertion sequences, first identified in the early 1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic resistance. Two IS, IS26 (found in many enterobacterial clinical isolates as components of both chromosome and plasmids) and IS257 (identified in the plasmids and chromosomes of gram-positive bacteria), have received particular attention for their clinical impact. Although few biochemical data are available concerning the transposition mechanism of these elements, genetic studies have provided some interesting observations suggesting that members of the family might transpose using an unexpected mechanism. In this review, we present an overview of the family, the distribution and phylogenetic relationships of its members, their impact on their host genomes and analyse available data concerning the particular transposition pathways they may use. We also provide a mechanistic model that explains the recent observations on one of the IS6 family transposition pathways: targeted cointegrate formation between replicons. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13100-021-00239-x. |
format | Online Article Text |
id | pubmed-7986276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79862762021-03-24 The IS6 family, a clinically important group of insertion sequences including IS26 Varani, Alessandro He, Susu Siguier, Patricia Ross, Karen Chandler, Michael Mob DNA Review The IS6 family of bacterial and archaeal insertion sequences, first identified in the early 1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic resistance. Two IS, IS26 (found in many enterobacterial clinical isolates as components of both chromosome and plasmids) and IS257 (identified in the plasmids and chromosomes of gram-positive bacteria), have received particular attention for their clinical impact. Although few biochemical data are available concerning the transposition mechanism of these elements, genetic studies have provided some interesting observations suggesting that members of the family might transpose using an unexpected mechanism. In this review, we present an overview of the family, the distribution and phylogenetic relationships of its members, their impact on their host genomes and analyse available data concerning the particular transposition pathways they may use. We also provide a mechanistic model that explains the recent observations on one of the IS6 family transposition pathways: targeted cointegrate formation between replicons. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13100-021-00239-x. BioMed Central 2021-03-23 /pmc/articles/PMC7986276/ /pubmed/33757578 http://dx.doi.org/10.1186/s13100-021-00239-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Varani, Alessandro He, Susu Siguier, Patricia Ross, Karen Chandler, Michael The IS6 family, a clinically important group of insertion sequences including IS26 |
title | The IS6 family, a clinically important group of insertion sequences including IS26 |
title_full | The IS6 family, a clinically important group of insertion sequences including IS26 |
title_fullStr | The IS6 family, a clinically important group of insertion sequences including IS26 |
title_full_unstemmed | The IS6 family, a clinically important group of insertion sequences including IS26 |
title_short | The IS6 family, a clinically important group of insertion sequences including IS26 |
title_sort | is6 family, a clinically important group of insertion sequences including is26 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986276/ https://www.ncbi.nlm.nih.gov/pubmed/33757578 http://dx.doi.org/10.1186/s13100-021-00239-x |
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