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Engineered Enzymes Enable Selective N‐Alkylation of Pyrazoles With Simple Haloalkanes

Selective alkylation of pyrazoles could solve a challenge in chemistry and streamline synthesis of important molecules. Here we report catalyst‐controlled pyrazole alkylation by a cyclic two‐enzyme cascade. In this enzymatic system, a promiscuous enzyme uses haloalkanes as precursors to generate non...

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Detalles Bibliográficos
Autores principales:	Bengel, Ludwig L., Aberle, Benjamin, Egler‐Kemmerer, Alexander‐N., Kienzle, Samuel, Hauer, Bernhard, Hammer, Stephan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986378/ https://www.ncbi.nlm.nih.gov/pubmed/33300646 http://dx.doi.org/10.1002/anie.202014239

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