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Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

BACKGROUND: Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (MGnD), which exhibit enhanced phagocytosis of plaques, a...

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Detalles Bibliográficos
Autores principales:	Clayton, Kevin, Delpech, Jean Christophe, Herron, Shawn, Iwahara, Naotoshi, Ericsson, Maria, Saito, Takashi, Saido, Takaomi C., Ikezu, Seiko, Ikezu, Tsuneya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986521/ https://www.ncbi.nlm.nih.gov/pubmed/33752701 http://dx.doi.org/10.1186/s13024-021-00440-9

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