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KCC2 Chloride Transport Contributes to the Termination of Ictal Epileptiform Activity
Recurrent seizures intensely activate GABA(A) receptors (GABA(A)-Rs), which induces transient neuronal chloride ([Cl(–)](i)) elevations and depolarizing GABA responses that contribute to the failure of inhibition that engenders further seizures and anticonvulsant resistance. The K(+)-Cl(–) cotranspo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society for Neuroscience
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986536/ https://www.ncbi.nlm.nih.gov/pubmed/33239270 http://dx.doi.org/10.1523/ENEURO.0208-20.2020 |