Cargando…

Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products

Natural product (NP) structures are a rich source of inspiration for the discovery of new biologically relevant chemical matter. In natural product inspired pseudo‐NPs, NP‐derived fragments are combined de novo in unprecedented arrangements. Described here is the design and synthesis of a 155‐member...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jie, Cremosnik, Gregor S., Otte, Felix, Pahl, Axel, Sievers, Sonja, Strohmann, Carsten, Waldmann, Herbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986669/ https://www.ncbi.nlm.nih.gov/pubmed/33200868 http://dx.doi.org/10.1002/anie.202013731

Ejemplares similares

Combination of Pseudo‐Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo‐Sesquiterpenoid Alkaloids
por: Liu, Jie, et al.
Publicado: (2021)

A Scaffold‐Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides
por: Zimmermann, Stefan, et al.
Publicado: (2019)

Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype
por: Burhop, Annina, et al.
Publicado: (2021)

Natural product fragment combination to performance-diverse pseudo-natural products
por: Grigalunas, Michael, et al.
Publicado: (2021)

Design, Synthesis, and Phenotypic Profiling of Pyrano‐Furo‐Pyridone Pseudo Natural Products
por: Christoforow, Andreas, et al.
Publicado: (2019)

Identification of a Novel Pseudo‐Natural Product Type IV IDO1 Inhibitor Chemotype
por: Davies, Caitlin, et al.
Publicado: (2022)

A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway
por: Liu, Jie, et al.
Publicado: (2023)

Pseudo Natural Products—Chemical Evolution of Natural Product Structure
por: Karageorgis, George, et al.
Publicado: (2021)

Phenotyping Reveals Targets of a Pseudo‐Natural‐Product Autophagy Inhibitor
por: Foley, Daniel J., et al.
Publicado: (2020)

Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex
por: Shaaban, Saad, et al.
Publicado: (2020)

Synthesis of Indomorphan Pseudo‐Natural Product Inhibitors of Glucose Transporters GLUT‐1 and ‐3
por: Ceballos, Javier, et al.
Publicado: (2019)

Synthesis of 20‐Membered Macrocyclic Pseudo‐Natural Products Yields Inducers of LC3 Lipidation
por: Niggemeyer, Georg, et al.
Publicado: (2022)

Rh(III)‐Catalyzed C−H Activation of Aryl Hydroxamates for the Synthesis of Isoindolinones
por: Shaaban, Saad, et al.
Publicado: (2020)

Pseudonatural Products Occur Frequently in Biologically Relevant Compounds
por: Gally, José-Manuel, et al.
Publicado: (2021)

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone
por: Grigalunas, Michael, et al.
Publicado: (2022)

The Pseudo‐Natural Product Rhonin Targets RHOGDI
por: Akbarzadeh, Mohammad, et al.
Publicado: (2022)

Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets
por: Schneidewind, Tabea, et al.
Publicado: (2020)

Crystal structure of 2-methyl-1,2,3,4-tetrahydroisoquinoline trihydrate
por: Langenohl, Felix, et al.
Publicado: (2020)

Crystal structure of N,N,N′,N′-tetramethylethanediamine
por: Schrimpf, Tobias, et al.
Publicado: (2022)

Natural Polypropionates in 1999–2020: An Overview of Chemical and Biological Diversity
por: Liu, Zhaoming, et al.
Publicado: (2020)

A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity
por: Lee, Yen-Chun, et al.
Publicado: (2017)

Natural products in chemical biology
por: Civjan, Natanya
Publicado: (2012)

Chemical Evolution of Natural Product Structure
por: Grigalunas, Michael, et al.
Publicado: (2022)

Crystal structures of diaquadi-μ-hydroxido-tris[trimethyltin(IV)] diformatotrimethylstannate(IV) and di-μ-hydroxido-tris[trimethyltin(IV)] chloride monohydrate
por: Otte, Felix, et al.
Publicado: (2016)

Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis
por: Crane, Erika A., et al.
Publicado: (2016)

Biological and Chemical Diversity of Ascidian-Associated Microorganisms
por: Chen, Lei, et al.
Publicado: (2018)

Enhancing chemical and biological diversity by co-cultivation
por: Selegato, Denise M., et al.
Publicado: (2023)

Spacial Score—A Comprehensive Topological Indicator for Small-Molecule Complexity
por: Krzyzanowski, Adrian, et al.
Publicado: (2023)

Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions
por: Yildirim, Okan, et al.
Publicado: (2021)

A review on biological and chemical diversity in Berberis (Berberidaceae)
por: Srivastava, Sharad, et al.
Publicado: (2015)

Harnessing synthetic biology to expand chemical diversity of antibiotics
por: Enam, Fatima
Publicado: (2021)

Diversity in Chemical Structures and Biological Properties of Plant Alkaloids
por: Bhambhani, Sweta, et al.
Publicado: (2021)

Crystal structures of [(N,N-dimethylamino)methyl]ferrocene and (R (p),R (p))-bis{2-[(dimethylamino)methyl]ferrocenyl}dimethylsilane
por: Krupp, Anna, et al.
Publicado: (2020)

Chemical and biological diversity of new natural products from marine sponges: a review (2009–2018)
por: Hong, Li-Li, et al.
Publicado: (2022)

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis
por: Narayan, Rishikesh, et al.
Publicado: (2014)

Trienamine catalyzed asymmetric synthesis and biological investigation of a cytochalasin B-inspired compound collection
por: Sellstedt, Magnus, et al.
Publicado: (2016)

Finding the region of pseudo-periodic tandem repeats in biological sequences
por: Liu, Xiaowen, et al.
Publicado: (2006)

Chemical Biology of Autophagy-Related Proteins With Posttranslational Modifications: From Chemical Synthesis to Biological Applications
por: Luo, Yu, et al.
Publicado: (2020)

Introduction to ‘Synthesis and chemical biology of macrocycles’
por: Chen, Gong, et al.
Publicado: (2022)

Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity
por: Thaker, Maulik N., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_i1t2t5e2cdk53lt1i79bjeqeck