An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt(II) Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates

The Pt(II) linker [ethylenediamineplatinum(II)](2+), coined Lx, has emerged as a novel non‐conventional approach to antibody–drug conjugates (ADCs) and has shown its potential in preclinical in vitro and in vivo benchmark studies. A crucial improvement of the Lx conjugation reaction from initially &...

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Detalles Bibliográficos
Autores principales: Merkul, Eugen, Muns, Joey A., Sijbrandi, Niels J., Houthoff, Hendrik‐Jan, Nijmeijer, Bart, van Rheenen, Gerro, Reedijk, Jan, van Dongen, Guus A. M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986738/
https://www.ncbi.nlm.nih.gov/pubmed/33185916
http://dx.doi.org/10.1002/anie.202011593

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