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Switch‐1 instability at the active site decouples ATP hydrolysis from force generation in myosin II

Myosin active site elements (i.e., switch‐1) bind both ATP and a divalent metal to coordinate ATP hydrolysis. ATP hydrolysis at the active site is linked via allosteric communication to the actin polymer binding site and lever arm movement, thus coupling the free energy of ATP hydrolysis to force ge...

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Detalles Bibliográficos
Autores principales:	Walker, Benjamin C., Walczak, Claire E., Cochran, Jared C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Short Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986744/ https://www.ncbi.nlm.nih.gov/pubmed/33381891 http://dx.doi.org/10.1002/cm.21650

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