Cargando…
Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986746/ https://www.ncbi.nlm.nih.gov/pubmed/33458965 http://dx.doi.org/10.1111/1756-185X.14060 |
_version_ | 1783668504313987072 |
---|---|
author | Xu, Jinjian Chen, Gang Yan, Zhen Qiu, Mochang Tong, Wentao Zhang, Xiaobin Zhang, Li Zhu, Yimin Liu, Keqi |
author_facet | Xu, Jinjian Chen, Gang Yan, Zhen Qiu, Mochang Tong, Wentao Zhang, Xiaobin Zhang, Li Zhu, Yimin Liu, Keqi |
author_sort | Xu, Jinjian |
collection | PubMed |
description | BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to evaluate the association between MBL gene polymorphisms and rheumatoid arthritis in a meta‐analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). RESULTS: Stratified analysis by ethnicities was conducted and the result revealed that rs1800450 (T vs C, OR = 1.32, 95% CI: 1.04‐1.67, P < .05) and MBL‐A/O (T vs C, OR = 1.20, 95% CI: 1.08‐1.34, P < .001) were strongly associated with RA in Brazilian populations. In addition, the significant relationship between rs11003125 (T vs C, OR = 1.16, 95% CI: 1.06‐1.26, P < .05) with RA were also observed in East Asian populations. Meanwhile, the inverse associations between rs5030737 with RA in East Asians and rs1800450 with RA in Indians were acquired. However, no association between any MBL polymorphism with RA susceptibility was confirmed in Caucasians. CONCLUSIONS: The structural polymorphisms in exon 1 of MBL gene may significantly contribute to susceptibility and development of RA in Brazilian and Indian populations, whereas the functional polymorphisms in the promoter region were more likely to associate with RA in East Asians. |
format | Online Article Text |
id | pubmed-7986746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79867462021-03-25 Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis Xu, Jinjian Chen, Gang Yan, Zhen Qiu, Mochang Tong, Wentao Zhang, Xiaobin Zhang, Li Zhu, Yimin Liu, Keqi Int J Rheum Dis Reviews and Recommendations BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to evaluate the association between MBL gene polymorphisms and rheumatoid arthritis in a meta‐analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). RESULTS: Stratified analysis by ethnicities was conducted and the result revealed that rs1800450 (T vs C, OR = 1.32, 95% CI: 1.04‐1.67, P < .05) and MBL‐A/O (T vs C, OR = 1.20, 95% CI: 1.08‐1.34, P < .001) were strongly associated with RA in Brazilian populations. In addition, the significant relationship between rs11003125 (T vs C, OR = 1.16, 95% CI: 1.06‐1.26, P < .05) with RA were also observed in East Asian populations. Meanwhile, the inverse associations between rs5030737 with RA in East Asians and rs1800450 with RA in Indians were acquired. However, no association between any MBL polymorphism with RA susceptibility was confirmed in Caucasians. CONCLUSIONS: The structural polymorphisms in exon 1 of MBL gene may significantly contribute to susceptibility and development of RA in Brazilian and Indian populations, whereas the functional polymorphisms in the promoter region were more likely to associate with RA in East Asians. John Wiley and Sons Inc. 2021-01-17 2021-03 /pmc/articles/PMC7986746/ /pubmed/33458965 http://dx.doi.org/10.1111/1756-185X.14060 Text en © 2021 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews and Recommendations Xu, Jinjian Chen, Gang Yan, Zhen Qiu, Mochang Tong, Wentao Zhang, Xiaobin Zhang, Li Zhu, Yimin Liu, Keqi Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title | Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title_full | Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title_fullStr | Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title_full_unstemmed | Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title_short | Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis |
title_sort | effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: evidence from a meta‐analysis |
topic | Reviews and Recommendations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986746/ https://www.ncbi.nlm.nih.gov/pubmed/33458965 http://dx.doi.org/10.1111/1756-185X.14060 |
work_keys_str_mv | AT xujinjian effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT chengang effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT yanzhen effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT qiumochang effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT tongwentao effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT zhangxiaobin effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT zhangli effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT zhuyimin effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis AT liukeqi effectofmannosebindinglectingenepolymorphismsontheriskofrheumatoidarthritisevidencefromametaanalysis |