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Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis

BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to...

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Autores principales: Xu, Jinjian, Chen, Gang, Yan, Zhen, Qiu, Mochang, Tong, Wentao, Zhang, Xiaobin, Zhang, Li, Zhu, Yimin, Liu, Keqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986746/
https://www.ncbi.nlm.nih.gov/pubmed/33458965
http://dx.doi.org/10.1111/1756-185X.14060
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author Xu, Jinjian
Chen, Gang
Yan, Zhen
Qiu, Mochang
Tong, Wentao
Zhang, Xiaobin
Zhang, Li
Zhu, Yimin
Liu, Keqi
author_facet Xu, Jinjian
Chen, Gang
Yan, Zhen
Qiu, Mochang
Tong, Wentao
Zhang, Xiaobin
Zhang, Li
Zhu, Yimin
Liu, Keqi
author_sort Xu, Jinjian
collection PubMed
description BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to evaluate the association between MBL gene polymorphisms and rheumatoid arthritis in a meta‐analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). RESULTS: Stratified analysis by ethnicities was conducted and the result revealed that rs1800450 (T vs C, OR = 1.32, 95% CI: 1.04‐1.67, P < .05) and MBL‐A/O (T vs C, OR = 1.20, 95% CI: 1.08‐1.34, P < .001) were strongly associated with RA in Brazilian populations. In addition, the significant relationship between rs11003125 (T vs C, OR = 1.16, 95% CI: 1.06‐1.26, P < .05) with RA were also observed in East Asian populations. Meanwhile, the inverse associations between rs5030737 with RA in East Asians and rs1800450 with RA in Indians were acquired. However, no association between any MBL polymorphism with RA susceptibility was confirmed in Caucasians. CONCLUSIONS: The structural polymorphisms in exon 1 of MBL gene may significantly contribute to susceptibility and development of RA in Brazilian and Indian populations, whereas the functional polymorphisms in the promoter region were more likely to associate with RA in East Asians.
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spelling pubmed-79867462021-03-25 Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis Xu, Jinjian Chen, Gang Yan, Zhen Qiu, Mochang Tong, Wentao Zhang, Xiaobin Zhang, Li Zhu, Yimin Liu, Keqi Int J Rheum Dis Reviews and Recommendations BACKGROUND: The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. MATERIALS AND METHODS: Fourteen articles involving 36 datasets were recruited to evaluate the association between MBL gene polymorphisms and rheumatoid arthritis in a meta‐analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). RESULTS: Stratified analysis by ethnicities was conducted and the result revealed that rs1800450 (T vs C, OR = 1.32, 95% CI: 1.04‐1.67, P < .05) and MBL‐A/O (T vs C, OR = 1.20, 95% CI: 1.08‐1.34, P < .001) were strongly associated with RA in Brazilian populations. In addition, the significant relationship between rs11003125 (T vs C, OR = 1.16, 95% CI: 1.06‐1.26, P < .05) with RA were also observed in East Asian populations. Meanwhile, the inverse associations between rs5030737 with RA in East Asians and rs1800450 with RA in Indians were acquired. However, no association between any MBL polymorphism with RA susceptibility was confirmed in Caucasians. CONCLUSIONS: The structural polymorphisms in exon 1 of MBL gene may significantly contribute to susceptibility and development of RA in Brazilian and Indian populations, whereas the functional polymorphisms in the promoter region were more likely to associate with RA in East Asians. John Wiley and Sons Inc. 2021-01-17 2021-03 /pmc/articles/PMC7986746/ /pubmed/33458965 http://dx.doi.org/10.1111/1756-185X.14060 Text en © 2021 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews and Recommendations
Xu, Jinjian
Chen, Gang
Yan, Zhen
Qiu, Mochang
Tong, Wentao
Zhang, Xiaobin
Zhang, Li
Zhu, Yimin
Liu, Keqi
Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title_full Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title_fullStr Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title_full_unstemmed Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title_short Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis
title_sort effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: evidence from a meta‐analysis
topic Reviews and Recommendations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986746/
https://www.ncbi.nlm.nih.gov/pubmed/33458965
http://dx.doi.org/10.1111/1756-185X.14060
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