HC‐HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors

Quiescence and self‐renewal of human corneal epithelial progenitor/stem cells (LEPC) are regulated by the limbal niche, presumably through close interaction with limbal (stromal) niche cells (LNC). Paired box homeotic gene 6 (Pax6), a conserved transcription factor essential for eye development, is...

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Detalles Bibliográficos
Autores principales: Chen, Szu‐Yu, Zhu, Yingting, Zhang, Yuan, Hsu, David, Tseng, Scheffer C.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986837/
https://www.ncbi.nlm.nih.gov/pubmed/33373496
http://dx.doi.org/10.1002/stem.3323

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