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CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy

BACKGROUND: Tumors often develop resistance to surveillance by endogenous immune cells, which include natural killer (NK) cells. Ex vivo activated and/or expanded NK cells demonstrate cytotoxicity against various tumor cells and are promising therapeutics for adoptive cancer immunotherapy. Genetic m...

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Detalles Bibliográficos
Autores principales:	Guo, Xuan, Mahlakõiv, Tanel, Ye, Qian, Somanchi, Srinivas, He, Shuyang, Rana, Hemlata, DiFiglia, Andrea, Gleason, Joseph, van der Touw, William, Hariri, Robert, Zhang, Xiaokui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986888/ https://www.ncbi.nlm.nih.gov/pubmed/33741730 http://dx.doi.org/10.1136/jitc-2020-001975

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