PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiol...

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Detalles Bibliográficos
Autores principales: de Waard, Antonius A., Verkerk, Tamara, Jongsma, Marlieke L. M., Hoefakker, Kelly, Sethumadhavan, Sunesh, Gerke, Carolin, Bliss, Sophie, Kong, Xiangrui, Janssen, George M. C., de Ru, Arnoud H., Claas, Frans H. J., Mulder, Arend, Tampé, Robert, van Veelen, Peter A., Halenius, Anne, Spaapen, Robbert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Technical Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986913/
https://www.ncbi.nlm.nih.gov/pubmed/33275281
http://dx.doi.org/10.1002/eji.202048599
Descripción
Sumario:A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiology, and autoimmunity. [Image: see text]

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