Cargando…
PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiol...
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986913/ https://www.ncbi.nlm.nih.gov/pubmed/33275281 http://dx.doi.org/10.1002/eji.202048599 |
| _version_ | 1783668534667116544 |
|---|---|
| author | de Waard, Antonius A. Verkerk, Tamara Jongsma, Marlieke L. M. Hoefakker, Kelly Sethumadhavan, Sunesh Gerke, Carolin Bliss, Sophie Kong, Xiangrui Janssen, George M. C. de Ru, Arnoud H. Claas, Frans H. J. Mulder, Arend Tampé, Robert van Veelen, Peter A. Halenius, Anne Spaapen, Robbert M. |
| author_facet | de Waard, Antonius A. Verkerk, Tamara Jongsma, Marlieke L. M. Hoefakker, Kelly Sethumadhavan, Sunesh Gerke, Carolin Bliss, Sophie Kong, Xiangrui Janssen, George M. C. de Ru, Arnoud H. Claas, Frans H. J. Mulder, Arend Tampé, Robert van Veelen, Peter A. Halenius, Anne Spaapen, Robbert M. |
| author_sort | de Waard, Antonius A. |
| collection | PubMed |
| description | A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiology, and autoimmunity. [Image: see text] |
| format | Online Article Text |
| id | pubmed-7986913 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79869132021-03-25 PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin de Waard, Antonius A. Verkerk, Tamara Jongsma, Marlieke L. M. Hoefakker, Kelly Sethumadhavan, Sunesh Gerke, Carolin Bliss, Sophie Kong, Xiangrui Janssen, George M. C. de Ru, Arnoud H. Claas, Frans H. J. Mulder, Arend Tampé, Robert van Veelen, Peter A. Halenius, Anne Spaapen, Robbert M. Eur J Immunol Technical Comment A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiology, and autoimmunity. [Image: see text] John Wiley and Sons Inc. 2021-02-01 2021-03 /pmc/articles/PMC7986913/ /pubmed/33275281 http://dx.doi.org/10.1002/eji.202048599 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Technical Comment de Waard, Antonius A. Verkerk, Tamara Jongsma, Marlieke L. M. Hoefakker, Kelly Sethumadhavan, Sunesh Gerke, Carolin Bliss, Sophie Kong, Xiangrui Janssen, George M. C. de Ru, Arnoud H. Claas, Frans H. J. Mulder, Arend Tampé, Robert van Veelen, Peter A. Halenius, Anne Spaapen, Robbert M. PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title | PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title_full | PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title_fullStr | PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title_full_unstemmed | PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title_short | PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin |
| title_sort | pakc: a novel panel of hla class i antigen presentation machinery knockout cells from the same genetic origin |
| topic | Technical Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986913/ https://www.ncbi.nlm.nih.gov/pubmed/33275281 http://dx.doi.org/10.1002/eji.202048599 |
| work_keys_str_mv | AT dewaardantoniusa pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT verkerktamara pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT jongsmamarliekelm pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT hoefakkerkelly pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT sethumadhavansunesh pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT gerkecarolin pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT blisssophie pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT kongxiangrui pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT janssengeorgemc pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT deruarnoudh pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT claasfranshj pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT mulderarend pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT tamperobert pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT vanveelenpetera pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT haleniusanne pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin AT spaapenrobbertm pakcanovelpanelofhlaclassiantigenpresentationmachineryknockoutcellsfromthesamegeneticorigin |