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Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia

Spina bifida, also known as meningomyelocele, is a major birth defect mostly associated with folate deficiency in the mother early in pregnancy. The prevalence of spina bifida is disproportionately high in Ethiopia compared to the global average; about 10,500 liveborn are affected annually. Many aff...

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Autores principales: Kancherla, Vijaya, Koning, Jan, Biluts, Hagos, Woldemariam, Mersha, Kibruyisfaw, Zewdie, Belete, Addisalem, Koning, Marinus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986934/
https://www.ncbi.nlm.nih.gov/pubmed/33319513
http://dx.doi.org/10.1002/bdr2.1857
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author Kancherla, Vijaya
Koning, Jan
Biluts, Hagos
Woldemariam, Mersha
Kibruyisfaw, Zewdie
Belete, Addisalem
Koning, Marinus
author_facet Kancherla, Vijaya
Koning, Jan
Biluts, Hagos
Woldemariam, Mersha
Kibruyisfaw, Zewdie
Belete, Addisalem
Koning, Marinus
author_sort Kancherla, Vijaya
collection PubMed
description Spina bifida, also known as meningomyelocele, is a major birth defect mostly associated with folate deficiency in the mother early in pregnancy. The prevalence of spina bifida is disproportionately high in Ethiopia compared to the global average; about 10,500 liveborn are affected annually. Many affected infants do not receive timely repair surgery. There are a high number of stillbirths, and neonatal, infant, and under‐five deaths. Mandatory fortification of staple foods such as wheat and maize flour with folic acid, a B vitamin, is an effective primary prevention strategy for spina bifida. Survival in those with spina bifida increases if neurosurgical intervention is available soon after birth, along with continuous surgical and clinical aftercare throughout the lifespan. Currently, Ethiopia does not have mandatory food fortification for primary prevention or adequate neurosurgical capacity to meet the need to prevent adverse outcomes associated with spina bifida. We present in this paper two concurrent and complementary policy and practice solutions occurring in Ethiopia through global partnerships: (1) capacity‐building of neurosurgery care through training programs; and (2) promoting national mandatory folic acid fortification of staples for primary prevention of spina bifida. These two policy and practice interventions ensure all affected infants can receive timely pediatric neurosurgery and sustained surgical aftercare through required neurosurgeon availability, and ensure primary prevention of spina bifida. Primary prevention of spina bifida frees up significant neurosurgical capacity in resource‐poor settings that can then be directed to other critical neurosurgical needs thus lowering child mortality and morbidity.
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spelling pubmed-79869342021-03-25 Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia Kancherla, Vijaya Koning, Jan Biluts, Hagos Woldemariam, Mersha Kibruyisfaw, Zewdie Belete, Addisalem Koning, Marinus Birth Defects Res Hypothesis Spina bifida, also known as meningomyelocele, is a major birth defect mostly associated with folate deficiency in the mother early in pregnancy. The prevalence of spina bifida is disproportionately high in Ethiopia compared to the global average; about 10,500 liveborn are affected annually. Many affected infants do not receive timely repair surgery. There are a high number of stillbirths, and neonatal, infant, and under‐five deaths. Mandatory fortification of staple foods such as wheat and maize flour with folic acid, a B vitamin, is an effective primary prevention strategy for spina bifida. Survival in those with spina bifida increases if neurosurgical intervention is available soon after birth, along with continuous surgical and clinical aftercare throughout the lifespan. Currently, Ethiopia does not have mandatory food fortification for primary prevention or adequate neurosurgical capacity to meet the need to prevent adverse outcomes associated with spina bifida. We present in this paper two concurrent and complementary policy and practice solutions occurring in Ethiopia through global partnerships: (1) capacity‐building of neurosurgery care through training programs; and (2) promoting national mandatory folic acid fortification of staples for primary prevention of spina bifida. These two policy and practice interventions ensure all affected infants can receive timely pediatric neurosurgery and sustained surgical aftercare through required neurosurgeon availability, and ensure primary prevention of spina bifida. Primary prevention of spina bifida frees up significant neurosurgical capacity in resource‐poor settings that can then be directed to other critical neurosurgical needs thus lowering child mortality and morbidity. John Wiley & Sons, Inc. 2020-12-14 2021-03-15 /pmc/articles/PMC7986934/ /pubmed/33319513 http://dx.doi.org/10.1002/bdr2.1857 Text en © 2020 The Authors. Birth Defects Research published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Hypothesis
Kancherla, Vijaya
Koning, Jan
Biluts, Hagos
Woldemariam, Mersha
Kibruyisfaw, Zewdie
Belete, Addisalem
Koning, Marinus
Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title_full Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title_fullStr Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title_full_unstemmed Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title_short Projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in Ethiopia
title_sort projected impact of mandatory food fortification with folic acid on neurosurgical capacity needed for treating spina bifida in ethiopia
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986934/
https://www.ncbi.nlm.nih.gov/pubmed/33319513
http://dx.doi.org/10.1002/bdr2.1857
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