Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

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The emergence of SARS-CoV in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV...

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Detalles Bibliográficos
Autores principales: Martinez, David R., Schäfer, Alexandra, Leist, Sarah R., De la Cruz, Gabriela, West, Ande, Atochina-Vasserman, Elena N., Lindesmith, Lisa C., Pardi, Norbert, Parks, Robert, Barr, Maggie, Li, Dapeng, Yount, Boyd, Saunders, Kevin O., Weissman, Drew, Haynes, Barton F., Montgomery, Stephanie A., Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986996/
https://www.ncbi.nlm.nih.gov/pubmed/33758837
http://dx.doi.org/10.1101/2021.03.11.434872

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