SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

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Pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here we investigated direct inflammatory functions of major structural proteins of SARS-CoV-2. We observed that spike (S) protein potently...

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Detalles Bibliográficos
Autores principales: Khan, Shahanshah, Shafiei, Mahnoush S., Longoria, Christopher, Schoggins, John, Savani, Rashmin C., Zaki, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987013/
https://www.ncbi.nlm.nih.gov/pubmed/33758854
http://dx.doi.org/10.1101/2021.03.16.435700
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