Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay

The papain-like protease (PL(pro)) of SARS-CoV-2 is a validated antiviral drug target. PL(pro) is involved in the cleavage of viral polyproteins and antagonizing host innate immune response through its deubiquitinating and deISG15ylating activities, rendering it a high profile antiviral drug target....

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Detalles Bibliográficos
Autores principales: Xia, Zilei, Sacco, Michael Dominic, Ma, Chunlong, Townsend, Julia Alma, Kitamura, Naoya, Hu, Yanmei, Ba, Mandy, Szeto, Tommy, Zhang, Xiujun, Meng, Xiangzhi, Zhang, Fushun, Xiang, Yan, Marty, Michael Thomas, Chen, Yu, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987026/
https://www.ncbi.nlm.nih.gov/pubmed/33758866
http://dx.doi.org/10.1101/2021.03.15.435551

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