Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid

Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary potential of this enteric virus. In animals lacking ty...

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Detalles Bibliográficos
Autores principales: Walker, Forrest C., Hassan, Ebrahim, Peterson, Stefan T., Rodgers, Rachel, Schriefer, Lawrence A., Thompson, Cassandra E., Li, Yuhao, Kalugotla, Gowri, Blum-Johnston, Carla, Lawrence, Dylan, McCune, Broc T., Graziano, Vincent R., Lushniak, Larissa, Lee, Sanghyun, Roth, Alexa N., Karst, Stephanie M., Nice, Timothy J., Miner, Jonathan J., Wilen, Craig B., Baldridge, Megan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987144/
https://www.ncbi.nlm.nih.gov/pubmed/33705489
http://dx.doi.org/10.1371/journal.ppat.1009402

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