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Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease

INTRODUCTION: Polyethylene glycol-electrolyte lavage solution plus ascorbic acid (PEG-ELS-Asc) has been recommended for colonoscopy, but little is known about the safety of PEG-ELS-Asc in patients with chronic kidney disease (CKD). The aim of this study was to determine its safety and efficacy in CK...

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Autores principales: Ohmiya, Naoki, Nakagawa, Yoshihito, Horiguchi, Noriyuki, Omori, Takafumi, Kamano, Toshiaki, Funasaka, Kohei, Nagasaka, Mitsuo, Shibata, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987408/
https://www.ncbi.nlm.nih.gov/pubmed/33815499
http://dx.doi.org/10.1155/2021/6696591
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author Ohmiya, Naoki
Nakagawa, Yoshihito
Horiguchi, Noriyuki
Omori, Takafumi
Kamano, Toshiaki
Funasaka, Kohei
Nagasaka, Mitsuo
Shibata, Tomoyuki
author_facet Ohmiya, Naoki
Nakagawa, Yoshihito
Horiguchi, Noriyuki
Omori, Takafumi
Kamano, Toshiaki
Funasaka, Kohei
Nagasaka, Mitsuo
Shibata, Tomoyuki
author_sort Ohmiya, Naoki
collection PubMed
description INTRODUCTION: Polyethylene glycol-electrolyte lavage solution plus ascorbic acid (PEG-ELS-Asc) has been recommended for colonoscopy, but little is known about the safety of PEG-ELS-Asc in patients with chronic kidney disease (CKD). The aim of this study was to determine its safety and efficacy in CKD patients. METHODS: Blood and urine samples prospectively collected before and after same-day bowel preparation for colonoscopy with the conventional volume of PEG-ELS-Asc, vital signs before and after colonoscopy, and adverse events within 30 days postcolonoscopy were analyzed in consenting patients with CKD. The cleansing level was evaluated with the Boston bowel preparation score (BBPS) from colonoscopic findings. RESULTS: Of 57 patients enrolled, 1 was excluded for refusal. Serum bicarbonate significantly dropped, and blood hemoglobin, serum total protein, albumin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, total bilirubin, and uric acid significantly rose after bowel preparation, although these changes were not clinically important. Only in nondialysis patients did the platelet count and potassium significantly rise, although these changes were not clinically important either. Renal function, such as the urea, creatinine, and estimated glomerular filtration rate, was not significantly altered. An adequate bowel cleansing score, BBPS ≥ 6, was achieved in 94% of patients. The blood pressure and heart rate were not significantly different between before and after colonoscopy in either nondialysis (n = 32) or dialysis (n = 19) patients. There were no adverse events associated with bowel preparation and colonoscopy within 30 days postcolonoscopy. CONCLUSIONS: The conventional volume of same-day bowel preparation with PEG-ELS-Asc may be safe and effective in CKD patients.
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spelling pubmed-79874082021-04-02 Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease Ohmiya, Naoki Nakagawa, Yoshihito Horiguchi, Noriyuki Omori, Takafumi Kamano, Toshiaki Funasaka, Kohei Nagasaka, Mitsuo Shibata, Tomoyuki Gastroenterol Res Pract Research Article INTRODUCTION: Polyethylene glycol-electrolyte lavage solution plus ascorbic acid (PEG-ELS-Asc) has been recommended for colonoscopy, but little is known about the safety of PEG-ELS-Asc in patients with chronic kidney disease (CKD). The aim of this study was to determine its safety and efficacy in CKD patients. METHODS: Blood and urine samples prospectively collected before and after same-day bowel preparation for colonoscopy with the conventional volume of PEG-ELS-Asc, vital signs before and after colonoscopy, and adverse events within 30 days postcolonoscopy were analyzed in consenting patients with CKD. The cleansing level was evaluated with the Boston bowel preparation score (BBPS) from colonoscopic findings. RESULTS: Of 57 patients enrolled, 1 was excluded for refusal. Serum bicarbonate significantly dropped, and blood hemoglobin, serum total protein, albumin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, total bilirubin, and uric acid significantly rose after bowel preparation, although these changes were not clinically important. Only in nondialysis patients did the platelet count and potassium significantly rise, although these changes were not clinically important either. Renal function, such as the urea, creatinine, and estimated glomerular filtration rate, was not significantly altered. An adequate bowel cleansing score, BBPS ≥ 6, was achieved in 94% of patients. The blood pressure and heart rate were not significantly different between before and after colonoscopy in either nondialysis (n = 32) or dialysis (n = 19) patients. There were no adverse events associated with bowel preparation and colonoscopy within 30 days postcolonoscopy. CONCLUSIONS: The conventional volume of same-day bowel preparation with PEG-ELS-Asc may be safe and effective in CKD patients. Hindawi 2021-03-15 /pmc/articles/PMC7987408/ /pubmed/33815499 http://dx.doi.org/10.1155/2021/6696591 Text en Copyright © 2021 Naoki Ohmiya et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ohmiya, Naoki
Nakagawa, Yoshihito
Horiguchi, Noriyuki
Omori, Takafumi
Kamano, Toshiaki
Funasaka, Kohei
Nagasaka, Mitsuo
Shibata, Tomoyuki
Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title_full Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title_fullStr Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title_full_unstemmed Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title_short Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease
title_sort safety of polyethylene glycol solution plus ascorbic acid for bowel preparation for colonoscopy in patients with chronic kidney disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987408/
https://www.ncbi.nlm.nih.gov/pubmed/33815499
http://dx.doi.org/10.1155/2021/6696591
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