A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children

BACKGROUND: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. METHODS: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF_V600E mutation by se...

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Detalles Bibliográficos
Autores principales: Phan, Thu Dang Anh, Phung, Bao Gia, Duong, Tu Thanh, Hoang, Vu Anh, Ngo, Dat Quoc, Trinh, Nguyen Dinh The, Tran, Tung Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987525/
https://www.ncbi.nlm.nih.gov/pubmed/33494131
http://dx.doi.org/10.4132/jptm.2020.11.30
Descripción
Sumario:BACKGROUND: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. METHODS: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF_V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. RESULTS: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF_V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. CONCLUSIONS: In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.

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