Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals

The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes....

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Detalles Bibliográficos
Autores principales: Kawaguchi, Shinji, Soma, Yusuke, Nakajima, Kazuaki, Kanazawa, Hideaki, Tohyama, Shugo, Tabei, Ryota, Hirano, Akinori, Handa, Noriko, Yamada, Yoshitake, Okuda, Shigeo, Hishikawa, Shuji, Teratani, Takumi, Kunita, Satoshi, Kishino, Yoshikazu, Okada, Marina, Tanosaki, Sho, Someya, Shota, Morita, Yuika, Tani, Hidenori, Kawai, Yujiro, Yamazaki, Masataka, Ito, Akira, Shibata, Rei, Murohara, Toyoaki, Tabata, Yasuhiko, Kobayashi, Eiji, Shimizu, Hideyuki, Fukuda, Keiichi, Fujita, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987543/
https://www.ncbi.nlm.nih.gov/pubmed/33778211
http://dx.doi.org/10.1016/j.jacbts.2020.11.017
Descripción
Sumario:The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study.

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