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Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals
The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987543/ https://www.ncbi.nlm.nih.gov/pubmed/33778211 http://dx.doi.org/10.1016/j.jacbts.2020.11.017 |
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| author | Kawaguchi, Shinji Soma, Yusuke Nakajima, Kazuaki Kanazawa, Hideaki Tohyama, Shugo Tabei, Ryota Hirano, Akinori Handa, Noriko Yamada, Yoshitake Okuda, Shigeo Hishikawa, Shuji Teratani, Takumi Kunita, Satoshi Kishino, Yoshikazu Okada, Marina Tanosaki, Sho Someya, Shota Morita, Yuika Tani, Hidenori Kawai, Yujiro Yamazaki, Masataka Ito, Akira Shibata, Rei Murohara, Toyoaki Tabata, Yasuhiko Kobayashi, Eiji Shimizu, Hideyuki Fukuda, Keiichi Fujita, Jun |
| author_facet | Kawaguchi, Shinji Soma, Yusuke Nakajima, Kazuaki Kanazawa, Hideaki Tohyama, Shugo Tabei, Ryota Hirano, Akinori Handa, Noriko Yamada, Yoshitake Okuda, Shigeo Hishikawa, Shuji Teratani, Takumi Kunita, Satoshi Kishino, Yoshikazu Okada, Marina Tanosaki, Sho Someya, Shota Morita, Yuika Tani, Hidenori Kawai, Yujiro Yamazaki, Masataka Ito, Akira Shibata, Rei Murohara, Toyoaki Tabata, Yasuhiko Kobayashi, Eiji Shimizu, Hideyuki Fukuda, Keiichi Fujita, Jun |
| author_sort | Kawaguchi, Shinji |
| collection | PubMed |
| description | The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study. |
| format | Online Article Text |
| id | pubmed-7987543 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79875432021-03-25 Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals Kawaguchi, Shinji Soma, Yusuke Nakajima, Kazuaki Kanazawa, Hideaki Tohyama, Shugo Tabei, Ryota Hirano, Akinori Handa, Noriko Yamada, Yoshitake Okuda, Shigeo Hishikawa, Shuji Teratani, Takumi Kunita, Satoshi Kishino, Yoshikazu Okada, Marina Tanosaki, Sho Someya, Shota Morita, Yuika Tani, Hidenori Kawai, Yujiro Yamazaki, Masataka Ito, Akira Shibata, Rei Murohara, Toyoaki Tabata, Yasuhiko Kobayashi, Eiji Shimizu, Hideyuki Fukuda, Keiichi Fujita, Jun JACC Basic Transl Sci Preclinical Research The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, cardiac regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) are realistic cell source for regenerative cardiomyocytes. The hiPSC-derived cardiomyocytes are highly expected to help the recovery of heart. Avoidance of teratoma formation and large-scale culture of cardiomyocytes are definitely necessary for clinical setting. The combination of pure cardiac spheroids and gelatin hydrogel succeeded to recover reduced ejection fraction. The feasible transplantation strategy including transplantation device for regenerative cardiomyocytes are established in this study. Elsevier 2021-02-19 /pmc/articles/PMC7987543/ /pubmed/33778211 http://dx.doi.org/10.1016/j.jacbts.2020.11.017 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preclinical Research Kawaguchi, Shinji Soma, Yusuke Nakajima, Kazuaki Kanazawa, Hideaki Tohyama, Shugo Tabei, Ryota Hirano, Akinori Handa, Noriko Yamada, Yoshitake Okuda, Shigeo Hishikawa, Shuji Teratani, Takumi Kunita, Satoshi Kishino, Yoshikazu Okada, Marina Tanosaki, Sho Someya, Shota Morita, Yuika Tani, Hidenori Kawai, Yujiro Yamazaki, Masataka Ito, Akira Shibata, Rei Murohara, Toyoaki Tabata, Yasuhiko Kobayashi, Eiji Shimizu, Hideyuki Fukuda, Keiichi Fujita, Jun Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title | Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title_full | Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title_fullStr | Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title_full_unstemmed | Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title_short | Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals |
| title_sort | intramyocardial transplantation of human ips cell–derived cardiac spheroids improves cardiac function in heart failure animals |
| topic | Preclinical Research |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987543/ https://www.ncbi.nlm.nih.gov/pubmed/33778211 http://dx.doi.org/10.1016/j.jacbts.2020.11.017 |
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