A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found...

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Detalles Bibliográficos
Autores principales: Li, Jing, Urabe, Go, Huang, Yitao, Zhang, Mengxue, Wang, Bowen, Marcho, Lynn, Shen, Hongtao, Kent, K. Craig, Guo, Lian-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987547/
https://www.ncbi.nlm.nih.gov/pubmed/33778212
http://dx.doi.org/10.1016/j.jacbts.2020.12.015
Descripción
Sumario:Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4’s phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis.

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