A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition

Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found...

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Autores principales: Li, Jing, Urabe, Go, Huang, Yitao, Zhang, Mengxue, Wang, Bowen, Marcho, Lynn, Shen, Hongtao, Kent, K. Craig, Guo, Lian-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987547/
https://www.ncbi.nlm.nih.gov/pubmed/33778212
http://dx.doi.org/10.1016/j.jacbts.2020.12.015
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author Li, Jing
Urabe, Go
Huang, Yitao
Zhang, Mengxue
Wang, Bowen
Marcho, Lynn
Shen, Hongtao
Kent, K. Craig
Guo, Lian-Wang
author_facet Li, Jing
Urabe, Go
Huang, Yitao
Zhang, Mengxue
Wang, Bowen
Marcho, Lynn
Shen, Hongtao
Kent, K. Craig
Guo, Lian-Wang
author_sort Li, Jing
collection PubMed
description Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4’s phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis.
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spelling pubmed-79875472021-03-25 A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition Li, Jing Urabe, Go Huang, Yitao Zhang, Mengxue Wang, Bowen Marcho, Lynn Shen, Hongtao Kent, K. Craig Guo, Lian-Wang JACC Basic Transl Sci Preclinical Research Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF’s nuclear activity and associated myofibroblast-like cell-type transition. In this context, we have further found that PLK4’s phosphorylation and transcription are respectively regulated by PDGF receptor and epigenetic factor BRD4. Furthermore, in vivo experiments suggest PLK4 inhibition as a potential approach to mitigating vascular fibrosis. Elsevier 2021-03-22 /pmc/articles/PMC7987547/ /pubmed/33778212 http://dx.doi.org/10.1016/j.jacbts.2020.12.015 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preclinical Research
Li, Jing
Urabe, Go
Huang, Yitao
Zhang, Mengxue
Wang, Bowen
Marcho, Lynn
Shen, Hongtao
Kent, K. Craig
Guo, Lian-Wang
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title_full A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title_fullStr A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title_full_unstemmed A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title_short A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition
title_sort role for polo-like kinase 4 in vascular fibroblast cell-type transition
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987547/
https://www.ncbi.nlm.nih.gov/pubmed/33778212
http://dx.doi.org/10.1016/j.jacbts.2020.12.015
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