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Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2

PURPOSE: Vitamin K-dependent proteins are involved in (patho)physiological calcification of the vasculature and the bones. Type 2 diabetes mellitus (DM2) is associated with increased arterial calcification and increased fractures. This study investigates the effect of 6 months vitamin K2 supplementa...

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Autores principales: Bartstra, Jonas W., Draaisma, Fieke, Zwakenberg, Sabine R., Lessmann, Nikolas, Wolterink, Jelmer M., van der Schouw, Yvonne T., de Jong, Pim A., Beulens, Joline W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987615/
https://www.ncbi.nlm.nih.gov/pubmed/33068157
http://dx.doi.org/10.1007/s00394-020-02412-z
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author Bartstra, Jonas W.
Draaisma, Fieke
Zwakenberg, Sabine R.
Lessmann, Nikolas
Wolterink, Jelmer M.
van der Schouw, Yvonne T.
de Jong, Pim A.
Beulens, Joline W. J.
author_facet Bartstra, Jonas W.
Draaisma, Fieke
Zwakenberg, Sabine R.
Lessmann, Nikolas
Wolterink, Jelmer M.
van der Schouw, Yvonne T.
de Jong, Pim A.
Beulens, Joline W. J.
author_sort Bartstra, Jonas W.
collection PubMed
description PURPOSE: Vitamin K-dependent proteins are involved in (patho)physiological calcification of the vasculature and the bones. Type 2 diabetes mellitus (DM2) is associated with increased arterial calcification and increased fractures. This study investigates the effect of 6 months vitamin K2 supplementation on systemic arterial calcification and bone mineral density (BMD) in DM2 patients with a history of cardiovascular disease (CVD). METHODS: In this pre-specified, post hoc analysis of a double-blind, randomized, controlled clinical trial, patients with DM2 and CVD were randomized to a daily, oral dose of 360 µg vitamin K2 or placebo for 6 months. CT scans were made at baseline and follow-up. Arterial calcification mass was quantified in several large arterial beds and a total arterial calcification mass score was calculated. BMD was assessed in all non-fractured thoracic and lumbar vertebrae. RESULTS: 68 participants were randomized, 35 to vitamin K2 (33 completed follow-up) and 33 to placebo (27 completed follow-up). The vitamin K group had higher arterial calcification mass at baseline [median (IQR): 1694 (812–3584) vs 1182 (235–2445)] for the total arterial calcification mass). Six months vitamin K supplementation did not reduce arterial calcification progression (β [95% CI]: − 0.02 [− 0.10; 0.06] for the total arterial calcification mass) or slow BMD decline (β [95% CI]: − 2.06 [− 11.26; 7.30] Hounsfield units for all vertebrae) when compared to placebo. CONCLUSION: Six months vitamin K supplementation did not halt progression of arterial calcification or decline of BMD in patients with DM2 and CVD. Future clinical trials may want to pre-select patients with very low vitamin K status and longer follow-up time might be warranted. This trial was registered at clinicaltrials.gov as NCT02839044
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spelling pubmed-79876152021-04-12 Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2 Bartstra, Jonas W. Draaisma, Fieke Zwakenberg, Sabine R. Lessmann, Nikolas Wolterink, Jelmer M. van der Schouw, Yvonne T. de Jong, Pim A. Beulens, Joline W. J. Eur J Nutr Original Contribution PURPOSE: Vitamin K-dependent proteins are involved in (patho)physiological calcification of the vasculature and the bones. Type 2 diabetes mellitus (DM2) is associated with increased arterial calcification and increased fractures. This study investigates the effect of 6 months vitamin K2 supplementation on systemic arterial calcification and bone mineral density (BMD) in DM2 patients with a history of cardiovascular disease (CVD). METHODS: In this pre-specified, post hoc analysis of a double-blind, randomized, controlled clinical trial, patients with DM2 and CVD were randomized to a daily, oral dose of 360 µg vitamin K2 or placebo for 6 months. CT scans were made at baseline and follow-up. Arterial calcification mass was quantified in several large arterial beds and a total arterial calcification mass score was calculated. BMD was assessed in all non-fractured thoracic and lumbar vertebrae. RESULTS: 68 participants were randomized, 35 to vitamin K2 (33 completed follow-up) and 33 to placebo (27 completed follow-up). The vitamin K group had higher arterial calcification mass at baseline [median (IQR): 1694 (812–3584) vs 1182 (235–2445)] for the total arterial calcification mass). Six months vitamin K supplementation did not reduce arterial calcification progression (β [95% CI]: − 0.02 [− 0.10; 0.06] for the total arterial calcification mass) or slow BMD decline (β [95% CI]: − 2.06 [− 11.26; 7.30] Hounsfield units for all vertebrae) when compared to placebo. CONCLUSION: Six months vitamin K supplementation did not halt progression of arterial calcification or decline of BMD in patients with DM2 and CVD. Future clinical trials may want to pre-select patients with very low vitamin K status and longer follow-up time might be warranted. This trial was registered at clinicaltrials.gov as NCT02839044 Springer Berlin Heidelberg 2020-10-17 2021 /pmc/articles/PMC7987615/ /pubmed/33068157 http://dx.doi.org/10.1007/s00394-020-02412-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Contribution
Bartstra, Jonas W.
Draaisma, Fieke
Zwakenberg, Sabine R.
Lessmann, Nikolas
Wolterink, Jelmer M.
van der Schouw, Yvonne T.
de Jong, Pim A.
Beulens, Joline W. J.
Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title_full Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title_fullStr Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title_full_unstemmed Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title_short Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
title_sort six months vitamin k treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987615/
https://www.ncbi.nlm.nih.gov/pubmed/33068157
http://dx.doi.org/10.1007/s00394-020-02412-z
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